Evidence map›Paper›PMID 42597238›Full record

ArticleAmerican journal of cancer research2026

Analysis of the relationship between immunological microenvironment and prognosis in pancreatic cancer.

Shuji Suzuki, Yuichi Nagakawa, Mitsugi Shimoda, Ryoichi Miyamoto, Masahiro Shiihara, Hiroaki Osakabe, Moe Matsumoto, Hiroshi Yamaguchi, Toshitaka Nagao

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Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shuji SuzukiDepartment of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University Ibaraki, Japan.
Yuichi NagakawaDepartment of Gastrointestinal and Pediatric Surgery, Tokyo Medical University Tokyo, Japan.
Mitsugi ShimodaDepartment of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University Ibaraki, Japan.
Ryoichi MiyamotoDepartment of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University Ibaraki, Japan.
Masahiro ShiiharaDepartment of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University Ibaraki, Japan.
Hiroaki OsakabeDepartment of Gastrointestinal and Pediatric Surgery, Tokyo Medical University Tokyo, Japan.
Moe MatsumotoDepartment of Gastrointestinal and Pediatric Surgery, Tokyo Medical University Tokyo, Japan.
Hiroshi YamaguchiDepartment of Pathology, Saitama Medical University Saitama, Japan.
Toshitaka NagaoDepartment of Anatomic Pathology, Tokyo Medical University Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune cell infiltration in tumors can serve as a prognostic marker in many cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) remains understudied. In this retrospective study, we aimed to evaluate the prognostic significance of the immunological microenvironment and immune cell infiltration in PDAC, considering both preoperative clinicophysiological and postoperative clinicopathological factors. Furthermore, we evaluated the same analyses after excluding patients who had received neoadjuvant treatment for the subgroup analysis. We included 189 patients who underwent radical resection for pancreatic cancer between October 2007 and October 2015 at our center and an affiliated university hospital. Immunohistochemical staining for clusters of differentiation (CD3, CD8, CD19, and CD20) was performed on the largest cross-sectional area of the tumor specimens to quantify immune cell infiltration. Disease-free survival (DFS) and overall survival (OS) were analyzed for each antigen. Preoperative clinicophysiological and postoperative clinicopathological factors were compared based on positively labeled cell counts. Among the 189 patients, 114 were men (average age, 69.3 years). CD20- and CD8-positive cell counts were significantly associated with DFS (

Indexed as

CD20CD8immunological microenvironmentpancreatic cancerprognostic factor

Identifiers

PMID42597238
PMCPMC13468254

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