ArticlePregnancy (Hoboken, N.J.)2025
Early pregnancy maternal lipid profile, acute phase responders, and the association with preterm delivery and selected pregnancy outcomes.
Article in Pregnancy (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: It is estimated that 30%-50% of spontaneous preterm deliveries (PTDs) are caused by infectious states. Acute-phase responders (APRs) accompany chronic as well as acute inflammatory states. In addition, hyperlipidemia is considered as a precursor of inflammation and oxidative stress. This study aimed to examine the associations between maternal serum levels of lipids and APRs in the 1st trimester of pregnancy and pregnancy outcomes. Methods: A prospective cohort study was conducted among multipara individuals with singleton pregnancies. Recruitment took place between 11 and 13 gestational weeks. The exposures were serum levels of the following APRs: C- reactive protein, albumin, triglyceride, total cholesterol, low density lipoprotein calculated (LDL-c), and high density lipoprotein. The outcomes were gestational diabetes mellitus, preeclampsia, gestational age at delivery, PTD (< 37 gestational weeks + 0 days), low birthweight, and macrosomia. Participants with the lowest or highest levels for each APR were identified based on clinical cut points. Multivariable analyses were performed to evaluate the independent association between the APRs and the studied outcomes, including linear models for gestational age at delivery or birthweight, and logistic models for PTD and other outcomes. Result: A total of 201 participants were included in the study. Mean birthweight was higher among individuals with high total cholesterol (3392.710 ± 426 g vs. 3220.782 ± 448 g, Conclusions: Higher birthweight was found among individuals with high early pregnancy total cholesterol and LDL-c levels, even after controlling for maternal BMI. Early monitoring of maternal lipid profile may serve as a useful predictor of excessive fetal growth, providing a potential tool for identifying pregnancies and individuals at higher risk for this complication, and which could benefit from closer observation. Levels of APRs were not associated with other pregnancy outcomes of interest.
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