SynthesisFrontiers in endocrinology2026
Triglyceride-glucose index and short-term mortality of adult patients with sepsis: a meta-analysis.
Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been associated with outcomes in sepsis, but existing evidence is inconsistent. This meta-analysis aimed to evaluate the association between a high TyG index and short-term mortality in adult patients with sepsis. Methods: A systematic search of PubMed, Embase, Web of Science, Wanfang, and CNKI was conducted to identify observational studies reporting the association between TyG index and short-term mortality (in-hospital or ≤30-day) in adult sepsis patients. Effect estimates were pooled using a random-effects model accounting for the influence of heterogeneity. Results: Eight retrospective cohort studies involving 14,772 patients were included. Overall, a higher TyG index was associated with increased short-term mortality (odds ratio [OR] 1.72, 95% confidence intervals 1.44-2.04; I² = 53%). Subgroup analyses showed consistent associations across mean age, proportion of men, and diabetic status (non-diabetic vs. mixed populations: Conclusions: A higher TyG index is associated with an increased risk of short-term mortality in adult patients with sepsis, supporting its potential role as a simple prognostic marker in clinical practice. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420261389660.
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