Evidence map›Paper›PMID 42597028›Full record

ArticlePregnancy (Hoboken, N.J.)2026

Impact of fat and protein on postprandial glycemia in gestational diabetes: A randomized pilot crossover trial.

Emily A Rosenberg, Tanayott Thaweethai, Diana C Soria-Contreras, Kaitlyn James, Estelle Kelty, Robin Azevedo, Sarah Lassey, Stacey Nelson, Sarah Hsu, Jamie Lynn Garry and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Pregnancy (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04187521 (Heterogeneity Informed Nutrition Therapy for Gestational Diabetes Mellitus), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04187521 nacompletednot on this map

Heterogeneity Informed Nutrition Therapy for Gestational Diabetes Mellitus

TypeinterventionalSponsorMassachusetts General HospitalRan2020 to 2022Enrolled19ConditionsGestational DiabetesArmsMeal A, Meal B
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emily A RosenbergDivision of Endocrinology, Diabetes and Metabolic Diseases Medical University of South Carolina Charleston South Carolina USA.
Tanayott ThaweethaiHarvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0003-0613-4176
Diana C Soria-ContrerasDiabetes Unit Massachusetts General Hospital Boston Massachusetts USA.
Kaitlyn JamesHarvard Medical School Boston Massachusetts USA.
Estelle KeltyDivision of Endocrinology, Diabetes and Hypertension Brigham and Women's Hospital Boston Massachusetts USA.
Robin AzevedoDiabetes Unit Massachusetts General Hospital Boston Massachusetts USA.
Sarah LasseyHarvard Medical School Boston Massachusetts USA.
Stacey NelsonDepartment of Obstetrics and Gynecology Massachusetts General Hospital Boston Massachusetts USA.
Sarah HsuClinical and Translational Epidemiology Unit Massachusetts General Hospital Boston Massachusetts USA.
Jamie Lynn GarryTranslational and Clinical Research Centers Massachusetts General Hospital Boston Massachusetts USA.
Ellen W SeelyHarvard Medical School Boston Massachusetts USA.
Camille E PoweHarvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-7060-7778

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Uncovering the Role of Dietary Fat and Protein in Glycemic Physiology in Pregnancy and in Gestational DiabetesF32DK126343 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSENBERG, EMILY · 2021 to 2022
$164k
NCATS NIH HHS UL1 TR002541NIDDK NIH HHS F32 DK126343
6 · The paper itself

Abstract

Background: The first-line treatment for gestational diabetes mellitus (GDM) is dietary modification, but there is little evidence on the impact of fat and protein on glycemia in pregnancy. Objective: To examine the effect of fat and protein on postprandial glycemia in individuals with GDM and to determine if this response differed in GDM characterized by insulin resistance versus insulin deficiency. Methods: We conducted a double-blind randomized crossover pilot study using test meals with similar caloric (390-411 kcal) and carbohydrate content (45%), but with either high-fat (41%) or high-protein (35%) content in diet-controlled GDM ( Results: The high-fat meal resulted in a higher mean (standard deviation [SD]) peak postprandial glucose (146.4 [19.7] mg/dL) than the high-protein meal (137.2 [21.1] mg/dL, Conclusion: In GDM, a high-protein meal leads to lower CGM-measured postprandial glucose compared to a high-fat meal, when calories and carbohydrate content are held constant. Trial Registration: ClinicalTrials.gov identifier: NCT04187521.

Indexed as

gestational diabetesnutritionpregnancy

Identifiers

PMID42597028
PMCPMC13344686

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.