ArticlePregnancy (Hoboken, N.J.)2025
Preclinical development of a continuous fetal lactate biosensor to detect acidosis.
Article in Pregnancy (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Accurate detection of fetal acidosis in labor is an unmet clinical need. Objectives of this study are: To run a pilot validation of a subcutaneous biosensor for continuous lactate monitoring (CLM) to detect acidosis in a fetal lamb model of asphyxia.Assess the feasibility of the CLM biosensor for intrapartum fetal monitoring by correlating sensor-detected lactate levels with contemporaneously collected blood lactate values. Method: Ewes ( Results: Nine biosensors were tested across three animals. Six of the nine had a clear response to lactate rise from an acute hypoxic event, with five of these having strong correlation ( Conclusion: This study demonstrates the capability of an innovative subcutaneous biosensor for CLM in detecting early signs of fetal lactic acidosis, highlighted by the strong correlation between sensor current and venous blood lactate levels. This technology has the potential to enable continuous fetal lactate measurement, with the ability to revolutionize intrapartum care and improve neonatal outcomes by enabling crucial early detection and management of fetal asphyxia during labor and delivery.
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