ArticlePregnancy (Hoboken, N.J.)2025
Outcomes in the immediate subsequent gestation following a pregnancy complicated by previable preterm prelabor rupture of membranes.
Article in Pregnancy (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Little is known about outcomes of subsequent gestation following a pregnancy complicated by previable/periviable preterm prelabor rupture of membrane (pPPROM). The objective of this study is to describe outcomes in subsequent gestation after a pregnancy complicated by pPPROM. Study design: We performed a retrospective cohort study of the subsequent pregnancy for patients with a history of pPPROM (rupture of membranes < 23 weeks) in the previous gestation of our institution from 2013 to 2022. All pregnancies were dated by ultrasound prior to pPPROM in the initial cohort. No anomalous fetuses were seen in this cohort. Subsequent pregnancies continuing beyond 13 weeks and 6 days were included in the analysis. Our primary outcome was gestational age (GA) at delivery in the subsequent pregnancy. Secondary outcomes included recurrent preterm birth (PTB), recurrent PPROM, and recurrent pPPROM. Secondary analysis was performed comparing patients delivering preterm versus term in subsequent pregnancy, and excluding patients missing delivery data or with loss < 14 weeks. Results: Of 100 patients with pPPROM, 42 patients (42%) had a subsequent pregnancy. Out of 42, 36 (85.7%) reached second trimester, 5 (11.9%) had first trimester loss, including one ectopic pregnancy of four spontaneous abortions at < 12 weeks, and one was lost to follow-up. Median GA at delivery in the subsequent pregnancy ( Conclusion: In patients with prior pPPROM with subsequent pregnancy continuing beyond the first trimester, more than two-thirds delivered at term in the subsequent pregnancy. However, recurrent previable PPROM occurred in 5.6% of patients. No clear risk factors for recurrent PTB (beyond PTB history) were identified in this cohort.
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