Predicting intrauterine vacuum-induced postpartum hemorrhage-control device treatment success.

Objective: To identify predictors of postpartum hemorrhage (PPH) treatment success with the JADA intrauterine vacuum-induced hemorrhage-control device in post-market settings. Methods: We performed a retrospective cohort study of PPH managed using the JADA system across 16 centers in the United States (NCT04995887). Treatment success was defined as no treatment escalation or PPH recurrence after device placement. Multivariable logistic regression was used to determine significant predictors of PPH treatment success with a stepwise model selection technique. Selection of the best performing model was determined using area under the receiver operating characteristic (AUC) curves, Akaike information criterion (AIC), and data completeness. In exploratory analyses, we assessed differences in treatment success by cause of bleeding and difference in time to device insertion by self-reported race, including an interaction term between race and insertion time. Results: From October 2020 to March 2022, 800 individuals had PPH managed with the JADA device. Most individuals delivered vaginally ( Conclusion: The two most important predictors of treatment success with JADA device were CBL prior to device insertion and the etiology of the bleeding. Understanding these factors may guide PPH treatment algorithms.