ArticlePregnancy (Hoboken, N.J.)2026
Examining buprenorphine compared to methadone for likelihood of overdose during pregnancy, 2014-2021.
Article in Pregnancy (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To examine the likelihood of experiencing an overdose among women receiving any buprenorphine (with or without naloxone) compared to women receiving methadone during pregnancy. Methods: Data from the MATernaL and Infant clinical NetworK (MAT-LINK), a longitudinal surveillance system of pregnant woman-child dyads using electronic health records (EHRs), were analyzed. Women from geographically diverse US clinical sites who had a diagnosis of opioid use disorder (OUD) during pregnancy, were prescribed medication for opioid use disorder (MOUD), and had a known birth outcome occurring between January 1, 2014 and August 31, 2021 were included. The Andersen-Gill Cox regression model for recurrent events with robust standard errors was used to model the effect of MOUD type by trimester on time to overdose or date of pregnancy outcome and calculate adjusted hazard ratios (aHRs). Results: Among the 3682 pregnancies included in this analysis, 46 (1.2%) had at least one EHR-documented overdose. None of the overdoses were fatal. In adjusted models, no differences in overdose were observed between pregnancies in which buprenorphine was prescribed or administered compared to pregnancies in which methadone was prescribed or administered (any drug overdose: aHR, 0.62; 95% CI, 0.31-1.23; opioid-involved overdose: aHR, 0.49; 95% CI, 0.18-1.30). In a trimester-specific sub-analysis of pregnancies with at least two MOUD prescriptions or administrations, taking buprenorphine in the third trimester resulted in a decreased likelihood of any drug overdose (aHR, 0.43; 95% CI, 0.20-0.93) and opioid-involved overdose (aHR, 0.32; 95% CI, 0.11-0.92) compared with methadone. Conclusion: It is important that women with OUD are initiated on the medication that works best for them as early as possible during pregnancy and that reinforcement of the importance of MOUD occurs throughout pregnancy, paying special attention to disruptions in treatment during the third trimester that might increase risk for overdose.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.