ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor-Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment.
Zhihao Zhang, Zijing Liu, Xiangyue Meng, Pengjun Jiang, Jie Qu, Yu Jiang, Binxu Qiu, Jie Chen, Piaopiao Chen
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Zhihao ZhangDepartment of Laboratory Medicine, Med+X Center for Manufacturing, Department of General Surgery, State Key Laboratory of Biotherapy, Department of Medical Oncology, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-3607-3151 Zijing LiuDepartment of Laboratory Medicine, Med+X Center for Manufacturing, Department of General Surgery, State Key Laboratory of Biotherapy, Department of Medical Oncology, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0009-2523-0527 Xiangyue MengDepartment of Laboratory Medicine, Med+X Center for Manufacturing, Department of General Surgery, State Key Laboratory of Biotherapy, Department of Medical Oncology, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Pengjun JiangDepartment of Laboratory Medicine, Med+X Center for Manufacturing, Department of General Surgery, State Key Laboratory of Biotherapy, Department of Medical Oncology, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jie QuDepartment of Laboratory Medicine, Med+X Center for Manufacturing, Department of General Surgery, State Key Laboratory of Biotherapy, Department of Medical Oncology, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yu JiangDepartment of Laboratory Medicine, Med+X Center for Manufacturing, Department of General Surgery, State Key Laboratory of Biotherapy, Department of Medical Oncology, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0003-0716-4334 Binxu QiuDepartment of Laboratory Medicine, Med+X Center for Manufacturing, Department of General Surgery, State Key Laboratory of Biotherapy, Department of Medical Oncology, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jie ChenDepartment of Laboratory Medicine, Med+X Center for Manufacturing, Department of General Surgery, State Key Laboratory of Biotherapy, Department of Medical Oncology, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0002-7712-5982 Piaopiao ChenDepartment of Laboratory Medicine, Med+X Center for Manufacturing, Department of General Surgery, State Key Laboratory of Biotherapy, Department of Medical Oncology, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-8158-9205 Funding
1·3·5 Project of State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University RHM24201Clinical Research Program for West China Hospital, Sichuan University 2022HXFH021Key Program of National Natural Science Foundation of China 32071284Key Program of National Natural Science Foundation of China 32371539Med-X Center for Manufacturing, West China Hospital, Sichuan University 0040206107018Med-X Center for Manufacturing, West China Hospital, Sichuan University 0040206107105Natural Science Foundation of Sichuan Province 2022NSFSC0736Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project 2026ZD01911300Sichuan Science and Technology Program 2024YFFK0306
6 · The paper itselfAbstract
Small extracellular vesicles (sEVs) carry biomolecules that reflect their cellular origin, making them attractive biomarkers for breast cancer assessment and human epidermal growth factor receptor 2 (HER2)-status discrimination. However, existing methods involve lengthy isolation procedures and exhibit poor detection performance due to severe interference from excessive impurities. In this study, we constructed a dual-target electrochemical (EC) sensing platform based on cascade aggregation effects. Combined with a facile filter-based isolation strategy, this enables rapid and convenient dual-marker (epithelial cell adhesion molecule (EpCAM) and HER2) analysis of breast cancer-derived sEVs. This mechanism relies on the target-triggered disassembly of DNA nanospheres to release Ag
Indexed as
breast cancer diagnosis and subtypingcontrollable cascade aggregationfilter isolationion‐programmed nanomachinestumor‐derived sEVs
Identifiers
PMID42596902
PMCPMC13474031
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