Evidence map›Paper›PMID 42596848›Full record

ArticleInternational journal of oncology2026

piR‑164552 promotes malignant progression in head and neck squamous cell carcinoma via the RBM4/EIF4E2 signaling axis: Insights from multi‑omics and functional analyses.

Shan Yang, Zhen Shang, Shunxian Xia, Hongbo Liu, Yanhan Dong, Xiaomin Wang, Wenhua Xu, Haijun Lu

Abstract read
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In one paragraph

Article in International journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shan YangDepartment of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.
Zhen ShangQingdao Medical College, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Shunxian XiaDepartment of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.
Hongbo LiuDepartment of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.
Yanhan DongQingdao Medical College, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Xiaomin WangInstitute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Wenhua XuInstitute of Regenerative Medicine and Laboratory Technology Innovation, Qingdao University, Qingdao, Shandong 266071, P.R. China.
Haijun LuDepartment of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy with limited options for early diagnosis and poor clinical outcomes. In the present study, PIWI‑interacting RNA (piR)‑164552 was identified as a novel oncogenic regulator in HNSCC. piR‑164552 was found to be markedly upregulated in tumor tissues and serum exosomes and its expression promoted the proliferation, migration, invasion and tumorigenicity of HNSCC cells both

Indexed as

Eukaryotic Initiation Factor-4EHead and Neck NeoplasmsPiwi-Interacting RNARNA-Binding ProteinsSquamous Cell Carcinoma of Head and NeckAnimalsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceBiomarkers, TumorEukaryotic Initiation Factor-4EPiwi-Interacting RNARBM4 protein, humanRNA-Binding Proteinseukaryotic initiation factor 4E‑like 2head and neck squamous cell carcinomaPIWI‑interacting RNAsRNA‑binding motif protein 4transcriptiontranslation

Identifiers

PMID42596848
PMCPMC13471134

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.