Evidence map›Paper›PMID 42596847›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026

Integrated analyses of in vivo mouse models and liver organoids reveal MFG-E8-mediated protection against hepatocyte injury.

Heng-Fu Bu, Qianming Jiang, Hua Geng, Saravanan Subramanian, Nazeer Hussain Khan, Xiao Wang, Xiao-Di Tan

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heng-Fu BuPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.ORCID 0000-0002-0311-8798
Qianming JiangPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.ORCID 0000-0001-9522-4856
Hua GengPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.
Saravanan SubramanianPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.ORCID 0000-0001-6607-3649
Nazeer Hussain KhanPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.
Xiao WangPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.ORCID 0000-0002-3198-0027
Xiao-Di TanPediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.ORCID 0000-0003-3766-5885

Funding

Insights into a multi-hit process in the development of necrotizing enterocolitisR01DK129960 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2022 to 2025
$2.6M
Mechanisms underlying regulation of intestinal epithelial homeostasis in sepsisR01DK123826 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TAN, XIAO-DI · 2020 to 2023
$2.4M
BLRD VA I01 BX006085HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK123826HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK129960NIDDK NIH HHS R01 DK123826NIDDK NIH HHS R01 DK129960U.S. Department of Veterans Affairs (VA) 101 BX006085
6 · The paper itself

Abstract

Milk fat globule-EGF factor 8 (MFG-E8) is a multifunctional glycoprotein implicated in tissue homeostasis and repair. Although its roles in intestinal and pancreatic injury are well established, its function in hepatic regeneration remains poorly defined. In this study, we investigated MFG-E8 expression and activity using a hepatocyte-specific apoptosis model (3xTg-iHAP) and liver organoid cultures from wild-type (B6

Indexed as

Antigens, SurfaceHepatocytesLiverLiver RegenerationMilk ProteinsOrganoidsAnimalsApoptosisMaleMiceMice, Inbred C57BLMice, KnockoutAntigens, SurfaceMfge8 protein, mouseMilk Proteinsferroptosishepatocyte apoptosisMFG-E8organoid culture

Identifiers

PMID42596847
PMCPMC13644301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.