α‑Cyperone targets the PAK1‑JNK/NF‑κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model.

Hang Hu, Xing Wang, Linlin Guo, Ziling Zeng, Hongmei Tang, Yun Zhang, Jiayao Duan, Kaijin Wang

Abstract read

In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hang Hu *Department of Respiratory and Critical Care Medicine, Bishan Hospital of Chongqing, Bishan Hospital of Chongqing Medical University, Chongqing 402760, P.R. China.

Xing Wang *Inflammation and Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Linlin Guo *Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Ziling ZengDepartment of Respiratory and Critical Care Medicine, Deyang People's Hospital, Deyang, Sichuan 618000, P.R. China.

Hongmei TangInflammation and Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Yun ZhangInflammation and Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Jiayao DuanInflammation and Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Kaijin WangDepartment of Respiratory and Critical Care Medicine, Bishan Hospital of Chongqing, Bishan Hospital of Chongqing Medical University, Chongqing 402760, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma is a common chronic airway inflammatory disease affecting millions of patients worldwide, and its treatment remains a clinical challenge. A variety of immune cells, cytokines and inflammatory mediators are associated with asthmatic pathogenesis. The α‑Cyperone (CYP) is the active ingredient of

Indexed as

AsthmaCell DifferentiationDendritic CellsNF-kappa Bp21-Activated KinasesTh2 CellsAnimalsDisease Models, AnimalFemaleMiceMice, Inbred BALB CSignal TransductionNF-kappa Bp21-Activated KinasesPak1 protein, mouseallergyasthmaJNKNF‑κBPAK1T cell; DCsα‑Cyperone

Identifiers

PMID42596835

DOI10.3892/ijmm.2026.5957

PMCPMC13502489

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.