Evidence map›Paper›PMID 42596833›Full record

ArticleInternational journal of molecular medicine2026

[Expression of Concern] Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway.

Xinying Zhang, Li Zhang, Zhe Chen, Siwei Li, Bingbing Che, Ningning Wang, Junting Chen, Changqing Xu, Can Wei

Abstract readExpression of Concern
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Xinying ZhangDepartment of Pathophysiology, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Li ZhangDepartment of Rehabilitation, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China.
Zhe ChenDepartment of Infectious Diseases, General Hospital for The Head Office of Agricultural Cultivation of Heilongjiang, Harbin, Heilongjiang 150088, P.R. China.
Siwei LiDepartment of Pathophysiology, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Bingbing CheDepartment of Pathophysiology, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Ningning WangDepartment of Pathophysiology, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Junting ChenDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Changqing XuDepartment of Pathophysiology, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Can WeiDepartment of Pathophysiology, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following the publication of the above paper, it was drawn to the Editor's attention by an interested reader that the CD‑2AP and podocin protein blots shown in Fig. 3A on p. 6 were strikingly similar, suggesting that the same data had apparently been used to represent the two different proteins. The authors have been contacted by the Editorial Office to offer an explanation for the apparent duplication of data in this figure, and we are awaiting their response. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [International Journal of Molecular Medicine 47: 27, 2021; DOI: 10.3892/ijmm.2021.4860].

Indexed as

AMP-Activated Protein KinasesDiabetes Mellitus, ExperimentalDiabetic NephropathiesSignal TransductionSpermineTOR Serine-Threonine KinasesAnimalsPodocytesRatsAMP-Activated Protein KinasesSpermineTOR Serine-Threonine KinasesAMPK/mTOR pathwayautophagydiabetic nephropathypodocytespermine

Identifiers

PMID42596833
PMCPMC13484812

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.