Evidence map›Paper›PMID 42596576›Full record

ArticleThe Australian journal of rural health2026

Strengthening Rural Health With N-of-1 Trials and Single-Case Experimental Designs.

Jane Nikles, Suzanne McDonald

Abstract readEditorial
In one paragraph

Article in The Australian journal of rural health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jane NiklesRECOVER Injury Research Centre, Surgical, Treatment and Rehabilitation Service (STARS), The University of Queensland, Brisbane, Australia.
Suzanne McDonaldGeneral Practice Clinical Unit, Medical School, The University of Queensland, Brisbane, Australia.ORCID 0000-0002-1745-4987

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

the challengeRural and remote clinicians frequently make treatment decisions under conditions of uncertainty, exacerbated by limited access to specialist services, fewer locally available treatment options, and evidence that may not fully inform care for an individual patient. THE OPPORTUNITY: N-of-1 trials and related single-case experimental designs (SCEDs) offer a structured method for generating individual-level evidence to support treatment decisions yet remain rarely used in routine clinical practice. Beyond informing care for individual patients, aggregated N-of-1 trials can also generate evidence that is directly relevant to rural populations and models of care. IMPLICATIONS: This editorial outlines the potential of N-of-1 trials and SCEDs in rural and remote health and argues that increasing awareness, training, and practical support could enable their wider adoption.

Indexed as

Research DesignRural HealthRural Health ServicesSingle-Case Studies as TopicAustraliaHumansN‐of‐1 trialsrural and remote healthsingle‐case experimental designs

Identifiers

PMID42596576
PMCPMC13473720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.