Evidence map›Paper›PMID 42596535›Full record

ArticleGut microbes2026

Dietary tryptophan mitigates lung ischemia-reperfusion injury in association with increased indole-3-propionate and aryl hydrocarbon receptor signaling.

Tomohiro Chaki, Daisuke Maruyama, Thien N M Doan, Xiaoli Tian, Arun Prakash

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Tomohiro ChakiDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8898-3977
Daisuke MaruyamaDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5285-9309
Thien N M DoanDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.
Xiaoli TianDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0971-9161
Arun PrakashDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1424-0932

Funding

The Gut-Lung Axis: Immunometabolism Linking the Gut Microbiome and Lung ImunityR01HL146753 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRAKASH BUDDE, ARUN · 2020 to 2024
$2.6M
NHLBI NIH HHS R01 HL146753
6 · The paper itself

Abstract

backgroundLung ischemia-reperfusion (IR) injury drives early morbidity after lung transplantation and cardiothoracic surgery, yet targeted preventive therapies are lacking. The gut-lung axis and microbiota-derived tryptophan metabolites, including indole-3-propionate (IPA), may regulate pulmonary immunity and inflammation. We investigated whether a tryptophan-rich (Trp-Rich) diet attenuates sterile lung IR injury by increasing microbiota-derived indole metabolites and reprogramming alveolar macrophage (AM) inflammatory responses.

methodsC57BL/6 mice receiving isocaloric tryptophan-standard (Trp-Std) or tryptophan-rich (Trp-Rich) diets underwent lung IR injury. Oxygen saturation, lung cytokines, and aryl hydrocarbon receptor (AhR) signaling readouts were evaluated. Gut microbiota was profiled by 16S rRNA sequencing, and targeted metabolomics quantified tryptophan metabolites in feces, portal vein (PV) plasma, and lung tissue. To further assess inflammatory priming

resultsTrp-Rich feeding improved post-IR oxygenation, reduced lung IL-1β, and increased pulmonary AhR-downstream gene expression. Trp-Rich diet remodeled gut microbiota, enriching for

conclusionsA Trp-Rich diet attenuated sterile lung IR injury, coinciding with gut microbiota remodeling, increased systemic and pulmonary IPA, reduced inflammatory priming, and reprogrammed AM responses. These data support diet- or microbiome-directed strategies targeting IPA-AhR signaling to mitigate perioperative lung IR injury.

Indexed as

IndolesLung InjuryReceptors, Aryl HydrocarbonReperfusion InjuryTryptophanAnimalsCytokinesDietGastrointestinal MicrobiomeHumansLungMacrophages, AlveolarMaleMiceMice, Inbred C57BLSignal TransductionCytokinesindolepropionic acidIndolesReceptors, Aryl HydrocarbonTryptophanalveolar macrophagearyl hydrocarbon receptordietary interventionindole-3-propionateindole derivativesIschemia-reperfusiontryptophan

Identifiers

PMID42596535
PMCPMC13479826

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.