Evidence map›Paper›PMID 42596526›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2026

Validation in adult Black and White women of the ISS model for estimating insulin sensitivity and beta-cell function from mixed-meal tests.

Arthur S Sherman, Nathan Sala, Anne E Sumner, Joon Ha, Stephanie T Chung

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Arthur S ShermanLaboratory of Biological Modeling, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0002-8372-5941
Nathan SalaSection on Pediatric Diabetes, Obesity, and Metabolism, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Anne E SumnerIntramural Research Program, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-9640-8999
Joon HaDepartment of Mathematics, Howard University, Washington, District of Columbia, United States.ORCID 0000-0003-4173-2534
Stephanie T ChungSection on Pediatric Diabetes, Obesity, and Metabolism, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-6989-0417

Funding

Modeling Pathogenesis of Type 2 DiabetesZIADK075137 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SHERMAN, ARTHUR · 2016 to 2025
$3.3M
Nested Study: Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and ContractorsZIADK075105 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CHUNG, STEPHANIE THERESE · 2014 to 2025
$1.8M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ZIA DK075137Intramural NIH HHS ZIA DK075105Intramural NIH HHS ZIA DK075137NSF | MPS | Division of Mathematical Sciences (DMS) DMS 2401921
6 · The paper itself

Abstract

The Insulin Sensitivity and Secretion (ISS) differential equation model has been previously shown to provide simultaneous estimates of insulin sensitivity (SI) and beta-cell function (BCF) during an oral glucose tolerance test. Using the Federal Women's Study, we adapted the ISS model to fit glucose and insulin dynamics and estimate SI and BCF during mixed-meal tests (MMTs). Our goal was to develop an effective, straightforward, and reliable tool that would be simpler to use than currently available approaches that require technically challenging deconvolution methods to assess BCF. The ISS model for mixed-meal tests strongly correlated with oral glucose tolerance tests and gold-standard estimates from intravenous glucose tolerance tests and was reliable when using a shortened 2-h MMT protocol. The ISS model is versatile, publicly available, and expands the toolbox for assessing postprandial glucose-insulin homeostasis.

Indexed as

InsulinInsulin ResistanceInsulin-Secreting CellsMealsModels, BiologicalAdultBlack or African AmericanBlood GlucoseFemaleGlucose Tolerance TestHumansInsulin SecretionMiddle AgedPostprandial PeriodWhiteBlood GlucoseInsulinbeta-cell functioninsulin sensitivityintravenous glucose tolerance testoral glucose tolerance test

Identifiers

PMID42596526
PMCPMC13632929

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.