Evidence map›Paper›PMID 42596509›Full record

ArticleJournal of medical primatology2026

Nonpathogenic SIV Infection in Sooty Mangabeys Is Characterized by a Lack of Activation and Expansion of Monocytes.

Caroline Soulas, Hai Duc Nguyen, Summer Siddiqui, Natalie Stahr, Tricia H Burdo, Francis J Novembre, Woong-Ki Kim, Kenneth C Williams

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Caroline SoulasBiology Department, Boston College, Chestnut Hill, Massachusetts, USA.
Hai Duc NguyenDivision of Microbiology, Tulane National Biomedical Research Center, Tulane University, Covington, Louisiana, USA.ORCID https://orcid.org/0000-0001-8419-7784
Summer SiddiquiDivision of Microbiology, Tulane National Biomedical Research Center, Tulane University, Covington, Louisiana, USA.ORCID https://orcid.org/0000-0002-5343-852X
Natalie StahrDivision of Microbiology, Tulane National Biomedical Research Center, Tulane University, Covington, Louisiana, USA.ORCID https://orcid.org/0000-0002-7611-8780
Tricia H BurdoBiology Department, Boston College, Chestnut Hill, Massachusetts, USA.ORCID https://orcid.org/0000-0002-4224-7381
Francis J NovembreDivsion of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Woong-Ki KimDivision of Microbiology, Tulane National Biomedical Research Center, Tulane University, Covington, Louisiana, USA.ORCID https://orcid.org/0000-0001-9964-185X
Kenneth C WilliamsBiology Department, Boston College, Chestnut Hill, Massachusetts, USA.

Funding

Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
MONOCYTE TRAFFIC AND THE NEUROPATHOGENESIS OF AIDSR01NS040237 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Robert Blair, Woong-Ki Kim · 1999 to 2026
$11.4M
Resource CoreP40OD028116 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2020 to 2026
$5.9M
Effects of CSF1R Blockade on Repopulation of SIV Reservoirs from the CNS to the Periphery After Antiretroviral Therapy InterruptionR01NS126091 · NINDS · BOSTON COLLEGE · PI KIM, WOONG-KI, WILLIAMS, KENNETH C · 2021 to 2025
$3.6M
NIAID NIH HHS U24 AI126683NIH HHS P40 OD028116NIH HHS R01NS040237NIH HHS R01NS126091NINDS NIH HHS R01 NS040237NINDS NIH HHS R01 NS126091
6 · The paper itself

Abstract

introductionNatural hosts of simian immunodeficiency virus (SIV), including sooty mangabeys (SMs), maintain high viremia without progressing to AIDS and AIDS-associated histopathogenesis. The mechanisms underlying this protection and lack of pathogenesis remain incompletely understood, particularly in relation to monocyte/macrophage activation.

methodsPlasma soluble CD163 (sCD163), monocyte CD163 expression, and monocyte subset phenotypes were quantified in uninfected and naturally SIV-infected SMs and compared with uninfected and SIV-infected rhesus macaques (RMs). Flow cytometry and multivariate analyses were used to assess monocyte activation and subset distribution.

resultssCD163 levels and CD163 surface expression were increased in SIV-infected RMs but not SMs. SIV-infected SMs exhibited reduced CD14

conclusionThese findings indicate a lack of monocyte activation in SMs that correlates with non-pathogenic infection.

Indexed as

Cercocebus atysMonocytesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenFlow CytometryMacaca mulattaReceptors, Cell SurfaceAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenReceptors, Cell SurfaceCCR8CD11bCD14CD16CD163sCD163SIV

Identifiers

PMID42596509
PMCPMC13473726

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.