ArticleChemMedChem2026
Synthesis and Biological Activity of 2,6-Disubstituted and 2,6,9-Trisubstituted 7-Deazapurine Nucleobases.
Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
High-throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6-diaryl-7-deazapurines. In this study, a series of 16 new 2,6-diaryl-7-deazapurine nucleobases together with four N-9 substituted derivatives were synthesized. The synthesis was based on regioselective Suzuki cross-coupling into position 6 followed by a second Suzuki cross-coupling at position 2 under harsher conditions. Both cross-couplings were performed on N-9 protected nucleobases. Biological activity profiling identified several potent antagonists of all four subtypes of ARs and four compounds as sub-micromolar and very selective antagonists of A
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Registered trials
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