ReviewTraffic (Copenhagen, Denmark)2026
Functional Specialization of Clathrin-Independent Endocytic Routes: Mechanisms and Cellular Roles.
Review in Traffic (Copenhagen, Denmark), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Clathrin-independent endocytosis (CIE) comprises a diverse repertoire of internalization mechanisms that operate in parallel with clathrin-mediated endocytosis. While these mechanisms share certain characteristics, they are governed by distinct molecular principles and regulatory logic. In this review, we provide an overview of CIE mechanisms, with a particular focus on the functional specialization of individual routes. We trace the historical emergence of CIE concepts and highlight how bacterial toxins and viruses have served as pivotal discovery tools, revealing lipid-driven and lectin-mediated mechanisms of membrane bending and internalization. Furthermore, we delineate the molecular frameworks of major CIE mechanisms and discuss experimental strategies for their dissection. We emphasize how the selection of a specific endocytic route dictates cargo fate, directing receptors and adhesion molecules toward recycling, retrograde trafficking, or degradation to modulate signaling amplitude, polarity, migration and epithelial barrier functions. Finally, we offer an evolutionary perspective on "coatless" CIE-like mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.