ArticleEye and vision (London, England)2026
Development of a predictive model for visual outcomes and risk factors of bilateral involvement for non-arteritic anterior ischemic optic neuropathy (NAION) in Chinese patients.
Article in Eye and vision (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundThis study aimed to explore the risk factors associated with bilateral involvement and to develop a predictive model for visual prognosis in Chinese patients with non-arteritic anterior ischemic optic neuropathy (NAION).
methodsIn this retrospective database-related meta-analysis, we retrospectively identified patients with NAION from the Chinese Neuro-Ophthalmic Diseases project database between September 2020 and December 2024. The clinical characteristics of the patients were summarized. Logistic and stepwise regression analyses were performed to identify the factors associated with bilateral involvement. Patients were randomly divided into training (75%) and validation (25%) cohorts. Least absolute shrinkage and selection operator (LASSO) and logistic regression analyses were used to develop a model for predicting factors associated with a best-corrected visual acuity (BCVA) ≤ 0.3 (decimal).
resultsThe study included 895 patients (560 [62.57%] males, 1,128 eyes; mean age: 55.6 ± 10.4 years). Bilateral NAION was present in 226 (25.3%) patients. At the follow-up examination, 522 patients (730 eyes) had a BCVA ≤ 0.3 in 369 (50.6%) eyes. Bilateral NAION involvement was associated with hyperlipidemia (t = 2.02, P = 0.04), hematologic disorders (t = 2.31, P = 0.02), and smoking (t = 4.79, P < 0.01). Risk factors for a BCVA ≤ 0.3 at follow-up were a lower BCVA at onset (odds ratio [OR] = 0.72, 95% confidence interval [CI]: 0.64-0.82, P < 0.01), diabetes mellitus (OR = 2.97, 95% CI: 1.10-8.03, P = 0.03), hyperhomocysteinemia (OR = 11.59, 95% CI: 1.87-71.97, P = 0.01), and macular serous detachment (OR = 6.70, 95% CI: 1.34-33.40, P = 0.02). The area under the receiver operating characteristic curve was 0.87 (95% CI: 0.83-0.87) for the training cohort and 0.86 (95% CI: 0.80-0.86) for the validation cohort.
conclusionsHyperlipidemia, hematologic disorders, and smoking were significant risk factors for bilateral NAION, whereas the severity of vision loss at onset, diabetes mellitus, hyperhomocysteinemia, and macular serous detachment were associated with poor visual prognosis in Chinese patients with NAION.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.