ArticleLipids in health and disease2026
Low-density lipoprotein cholesterol is inversely associated with left atrial low-voltage areas in patients with persistent atrial fibrillation: a retrospective cohort study.
Article in Lipids in health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundLeft atrial low-voltage areas (LVAs) reflect advanced atrial remodeling and are associated with postablation recurrence in patients with persistent atrial fibrillation (PerAF). However, the relationship between routinely measured metabolic parameters and LVAs remains insufficiently characterized. This study aimed to identify clinical factors associated with LVAs in patients with PerAF, with particular emphasis on metabolic parameters.
methodsThis retrospective single-center cohort included consecutive PerAF patients who underwent initial catheter ablation between January 2021 and August 2024. LVA status was analyzed as a binary outcome based on the results of the intraprocedural substrate assessment. Logistic regression was used to assess associations with LVAs, while mediation, restricted cubic spline, and quartile-based analyses were conducted as secondary analyses; the quartile-based analyses were descriptive. Postablation recurrence was assessed by Kaplan-Meier and Cox analyses.
resultsAmong 404 patients, 232 (57.4%) had LVAs. Age, female sex, fibrillatory wave amplitude, left atrial diameter (LAD), and LDL-C levels were associated with the presence of LVAs. Higher LDL-C levels were associated with lower odds of LVAs (odds ratio [OR] 0.72 per mmol/L, 95% confidence interval [CI] 0.53-0.97). LAD may partly account for this association (15%-18%). Quartile-based analyses revealed heterogeneity in LVA prevalence and recurrence across LDL-C categories, but these results were descriptive.
conclusionIn patients with PerAF, higher LDL-C levels were independently associated with a lower likelihood of LVAs. Lower LDL-C levels may help identify patients with a higher likelihood of advanced atrial remodeling before ablation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.