Evidence map›Paper›PMID 42595907›Full record

ArticleSurgical endoscopy2026

Prophylactic antibiotics after peroral endoscopic myotomy may not significantly reduce postprocedural fever or infection: a propensity score matching analysis.

Qiang Yang, Foqiang Liao, Tingting Jiang, Shuman Guo, Jianfang Rong, Zhenhua Zhu, Xiaolin Pan, Shunhua Long, Yin Zhu, Xiaoming Liu and 1 more

Abstract read
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Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Qiang Yang *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Foqiang Liao *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Tingting Jiang *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Shuman GuoThe First Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Jianfang RongDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Zhenhua ZhuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Xiaolin PanDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Shunhua LongDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Yin ZhuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Xiaoming LiuDepartment of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China. lxmhy906@163.com.
Xu ShuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China. jxmushx@126.com.ORCID http://orcid.org/0000-0002-0861-5742

Funding

Double Thousand Plan of Jiangxi Province jxsq2023201044National Natural Science Foundation of China No. 82360119National Natural Science Foundation of China No. 82560122Young Scholar Project of the First Affiliated Hospital of Nanchang University YFYPY202532
6 · The paper itself

Abstract

backgroundPeroral endoscopic myotomy (POEM) has become a standard treatment for achalasia. Routine prophylactic antibiotics are still widely used after POEM, although clinical evidence supporting this common practice remains limited. This study aims to evaluate the clinical necessity of routine postoperative prophylactic antibiotics in patients with achalasia undergoing POEM.

methodsWe conducted a retrospective analysis of 340 achalasia patients who underwent POEM at the First Affiliated Hospital of Nanchang University between January 2012 and December 2024. Based on postoperative prophylactic antibiotic use, patients were divided into two groups: the prophylactic antibiotic (PA) group and the non-prophylactic antibiotic (non-PA) group. To minimize selection bias, 1:1 propensity score matching (PSM) was performed with a caliper of 0.1.

resultsIn the overall cohort, patients were divided into PA group (n = 279, 82.1%) and non-PA group (n = 61, 17.9%). After matching, the baseline characteristics of the 56 patients in the PA group were well-balanced with those of the 56 patients in the non-PA group (all p > 0.05). There were no significant differences between the two groups in the incidence of postprocedural fever, infection or the median length of hospital stay (p > 0.05). In the full-thickness myotomy subgroup, there were no significant differences between the two groups in the incidence of postprocedural fever and infection. However, the incidence of cough was significantly higher in the non-PA group compared to the PA group (p = 0.040).

conclusionRoutine prophylactic antibiotics after POEM for patients with achalasia may not significantly reduce postprocedural fever, infection, or length of hospital stay.

Indexed as

AchalasiaPeroral endoscopic myotomyPropensity score matchingProphylactic antibiotics

Identifiers

PMID42595907

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.