Evidence map›Paper›PMID 42595852›Full record

ArticleCellular & molecular immunology2026

Radiation-induced CD200

Kun Li, Siqi Li, Dongbo Qiu, Xiusheng Qiu, Haoyuan Yu, Yi Xiong, Wei Liang, Zhixing Liang, Shuqun Cheng, Hua Li and 3 more

Abstract read
In one paragraph

Article in Cellular & molecular immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kun Li *Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Siqi Li *Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Dongbo Qiu *Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xiusheng QiuCell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Haoyuan YuDepartment of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yi XiongCell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Wei LiangCell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhixing LiangDepartment of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Shuqun ChengDepartment of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Hua LiDepartment of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. lihua100@yeah.net.
Yunfei QinCell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. qinyf6@mail.sysu.edu.cn.
Yang YangDepartment of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. yysysu@163.com.ORCID 0000-0003-4981-4745
Linsen YeDepartment of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. ye_linsen@163.com.

Funding

China Postdoctoral Science Foundation 2025M772097National Natural Science Foundation of China (National Science Foundation of China) 82470611National Natural Science Foundation of China (National Science Foundation of China) 82500782National Natural Science Foundation of China (National Science Foundation of China) 82503851National Natural Science Foundation of China (National Science Foundation of China) 82570739Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2023A1515011615Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2025A1515011223Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2026A1515010324Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2026A1515012816
6 · The paper itself

Abstract

Radiotherapy elicits dual immunomodulatory effects in cancer, activating antitumor immunity while paradoxically inducing immunosuppression, which limits therapeutic efficacy. The molecular pathways mediating postradiation immune escape in hepatocellular carcinoma (HCC) remain poorly defined. Here, we elucidate a previously uncharacterized mechanism whereby radiotherapy drives the accumulation of CD200

Indexed as

Antigens, CDCarcinoma, HepatocellularEosinophilsLiver NeoplasmsOrexin ReceptorsSignal TransductionTumor-Associated MacrophagesAnimalsCell Line, TumorFemaleHumansNF-kappa BAntigens, CDantigens, CD200CD200R1 protein, humanNF-kappa BOrexin ReceptorsCD200ImmunotherapyRadiotherapySTINGTAMs

Identifiers

PMID42595852
PMCPMC13526841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.