Evidence map›Paper›PMID 42595771›Full record

ArticleInternational journal of obesity (2005)2026

High resolution lipoprotein subfraction profiling identifies obesity associated distributional changes in LDL and HDL subfractions and particle ratios.

Novia Minaee, Reika Masuda, Philipp Nitschke, Drew Hall, Jennie Hui, Michael L Hunter, Leon Flicker, Graeme J Hankey, Osvaldo P Almeida, Dick C Chan and 14 more

Abstract read
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Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Novia MinaeeCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA, Australia.
Reika MasudaCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA, Australia.
Philipp NitschkeCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA, Australia.
Drew HallCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA, Australia.
Jennie HuiBusselton Population Medical Research Institute, Busselton, WA, Australia.
Michael L HunterBusselton Population Medical Research Institute, Busselton, WA, Australia.ORCID http://orcid.org/0000-0001-6704-4815
Leon FlickerMedical School, University of Western Australia, Perth, WA, Australia.
Graeme J HankeyMedical School, University of Western Australia, Perth, WA, Australia.
Osvaldo P AlmeidaMedical School, University of Western Australia, Perth, WA, Australia.ORCID http://orcid.org/0000-0002-8689-6199
Dick C ChanMedical School, University of Western Australia, Perth, WA, Australia.ORCID http://orcid.org/0000-0001-7658-5197
Gerald F WattsMedical School, University of Western Australia, Perth, WA, Australia.
Muhammad Saeed AhmadDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Huda M AlkreathyDrug Metabolism Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Zoheir Abdullah DhamanouriDrug Metabolism Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Hartmut SchäferBruker Biospin GmbH & Co. Kg, Ettlingen, Germany.
Manfred SpraulBruker Biospin GmbH & Co. Kg, Ettlingen, Germany.
Claire CannetBruker Biospin GmbH & Co. Kg, Ettlingen, Germany.
John P BeilbyBusselton Population Medical Research Institute, Busselton, WA, Australia.
Bu B YeapMedical School, University of Western Australia, Perth, WA, Australia.
Oscar MilletPrecision Medicine and Metabolism Laboratory, CIC bioGUNE, Parque Tecnológico de Bizkaia, Derio, Spain.
Julien WistCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA, Australia.ORCID http://orcid.org/0000-0002-3416-2572
Jeremy K NicholsonInstitute of Global Health Innovation, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-8123-8349
Samantha LodgeCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA, Australia. sam.lodge@murdoch.edu.au.ORCID http://orcid.org/0000-0001-9193-0462
Elaine HolmesSchool of Medicine, The Hong Kong University of Science and Technology, Hong Kong, China. elaineholmes@ust.hk.ORCID http://orcid.org/0000-0002-0556-8389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is associated with adverse alterations in lipoprotein profiles and increased cardiometabolic risk, yet standard clinical lipid measures provide limited resolution of the underlying lipoprotein structure. Here, we perform a population-level characterisation of the impact of obesity on the high-resolution blood lipoprotein subfraction profile.

methodsLipoprotein profiles were investigated in an Australian cohort (n = 1806) stratified by Body Mass Index (BMI) (healthy weight, overweight, obese). The composition and particle number of lipoproteins and their subfractions were quantified (n = 112 parameters) using

conclusionsThe pattern of lipoprotein subfraction redistribution in participants with obesity was consistent across cohorts. These subfractional changes offer enhanced resolution compared with conventional lipid and lipoprotein measures and may contribute to improved cardiovascular risk stratification in individuals with obesity.

Identifiers

PMID42595771

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.