Evidence map›Paper›PMID 42595758›Full record

ArticleNature communications2026

Drops in confidence precede symptoms of obsessive-compulsive disorder.

A A Marzuki, L A Kosina, L Dome, S R C Hewitt, T U Hauser

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A A MarzukiDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, Tübingen University, Tübingen, Germany. aleya.a.marzuki@gmail.com.ORCID http://orcid.org/0000-0002-8497-7112
L A KosinaDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, Tübingen University, Tübingen, Germany.
L DomeDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, Tübingen University, Tübingen, Germany.ORCID http://orcid.org/0000-0001-7487-1974
S R C HewittMax Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK.ORCID http://orcid.org/0000-0002-9219-6324
T U HauserDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, Tübingen University, Tübingen, Germany.ORCID http://orcid.org/0000-0002-7997-8137

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mental health symptoms, like those in obsessive-compulsive disorder, show pronounced fluctuations over time. However, little is known about the underlying factors driving these fluctuations. Whilst theoretical accounts propose that cognitive processes drive symptom variability, cross-sectional work is unable to effectively probe these mechanisms. Based on prevailing notions of doubt and underconfidence being cognitive hallmarks of the disorder, we investigate whether metacognitive processes correspond to obsessive-compulsive disorder symptoms. We employ a smartphone-based momentary assessment design wherein participants with obsessive-compulsive disorder (N = 137) log instances of experiencing symptoms across 2-weeks. Participants also complete daily scheduled assessments and play a perceptual metacognitive task every two days. Our results reveal that metacognition is associated with obsessive-compulsive symptoms. Concretely, we find directional effects whereby reductions in both self-confidence and task-based metacognition precede occurrences of obsessive-compulsive symptom logs, but not vice versa. Moreover, confidence during perceptual decision-making is significantly related to self-reported confidence on a moment-to-moment basis, indicating that distinct metacognitive modalities may be interrelated. Results remain robust in the face of several sensitivity analyses targeting possible imbalances and missingness in the data. Thus, our micro-longitudinal study design provides evidence for cognitive distortions (both self-reported and task-based) preceding symptom escalations, signifying the potential for designing just-in-time interventions.

Indexed as

MetacognitionObsessive-Compulsive DisorderSelf ConceptAdultDecision MakingFemaleHumansMaleSelf ReportYoung Adult

Identifiers

PMID42595758
PMCPMC13473584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.