ArticleEuropean journal of clinical investigation2026
Evaluation of Liver Grafts During Machine Perfusion at 20°C via Metabolization of 13C-Methacetin.
Article in European journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEvaluative measures, helping to decide whether a marginal graft can be used for transplantation or rather be discarded are of utmost importance but yet basically underdeveloped. Recent technical developments allow for the isolated detection of 13C-labelled carbon dioxide in the oxygenator exhaust of an isolated perfused organ. By adding a 13C-labelled tracer, its metabolism can be monitored by measuring the increase in 13C carbon in the exhaust air. Here we evaluated the potential of the technique to evaluate pig livers during machine perfusion.
methodsPorcine livers (six per group) were subjected to 5, 20 or 45 min of warm ischemia and cold stored overnight. Evaluative machine perfusion was done with MPS at 20°C for 2 h. After injection of 13C-methacetin as a tracer,
resultsThe
conclusionThus, the 13C turnover test appears to have the potential of an objective, quantitative and valuable adjunct in the toolbox for pre-transplant evaluation of questionable liver grafts.
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