ArticleDiabetes, obesity & metabolism2026
Age-Specific Associations of Moderate-to-Vigorous Physical Activity With Relative and Absolute Risk of Type 2 Diabetes in UK Biobank Participants.
Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Age-Specific Associations of Moderate-to-Vigorous Physical Activity With Relative and Absolute Risk of Type 2 Diabetes in UK Biobank Participants.Diabetes, obesity & metabolism · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
aimsWe assessed the age-specific associations between moderate-to-vigorous physical activity (MVPA) and incident type 2 diabetes. MATERIALS AND
methodsWe included UK Biobank participants with valid accelerometry data without diabetes mellitus at baseline (N = 87 975; 62.7 years [IQR, 55.6-67.9]; 57% women). We examined whether age, sex and baseline metabolic disease status modified the associations of MVPA volume (lower versus higher) and, in exploratory analyses, MVPA timing (later-day versus earlier-day) with incident type 2 diabetes. Age-specific relative and absolute associations were assessed across 5-year age bins using hazard ratios (HRs) and incidence rate differences (IRDs), and additionally stratified by sex and baseline metabolic disease status.
resultsAssociations of MVPA volume with type 2 diabetes were most consistently modified by age, baseline prediabetes (all p-values for interaction < 0.05), with stronger associations observed among participants younger than the median population age (< 62.7 years, HR = 2.44 [95% CI: 2.05-2.90] versus HR = 1.65 [95% CI: 1.47-1.86]) and participants without prediabetes. Across 5-year age groups, HRs declined with age, whereas IRDs increased in the overall population. No clear effect modification was observed for the association between MVPA timing and type 2 diabetes risk.
conclusionsThe relative association between higher MVPA volume and lower type 2 diabetes risk attenuated with age and was weaker among individuals with prediabetes, whereas absolute risk reductions were larger among older and metabolically higher-risk individuals. These findings support considering both relative and absolute measures when targeting MVPA interventions for type 2 diabetes prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.