Evidence map›Paper›PMID 42595101›Full record

Trial reportBrain stimulation

Dose dependent effects of transcranial photobiomodulation on blood-oxygenation-level-dependent power in major depressive disorder.

Dan V Iosifescu, Katherine A Collins, Umit Tural, Jacek P Dmochowski, Naomi Gaggi, Zamfira Parincu, Anna Peterson, Aura M Hurtado-Puerto, Maia B Gersten, Julie A Clancy and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dan V IosifescuClinical Research Division, The Nathan Kline Institute for Psychiatric Research, USA; Department of Psychiatry, New York University Grossman School of Medicine, USA. Electronic address: dan.iosifescu@nyulangone.org.
Katherine A CollinsClinical Research Division, The Nathan Kline Institute for Psychiatric Research, USA.
Umit TuralClinical Research Division, The Nathan Kline Institute for Psychiatric Research, USA.
Jacek P DmochowskiDepartment of Biomedical Engineering, City University of New York, USA.
Naomi GaggiClinical Research Division, The Nathan Kline Institute for Psychiatric Research, USA; Department of Psychiatry, New York University Grossman School of Medicine, USA.
Zamfira ParincuClinical Research Division, The Nathan Kline Institute for Psychiatric Research, USA; Department of Psychiatry, New York University Grossman School of Medicine, USA.
Anna PetersonDepartment of Psychiatry, New York University Grossman School of Medicine, USA.
Aura M Hurtado-PuertoDivision of Neuropsychiatry, Massachusetts General Hospital, USA.
Maia B GerstenDivision of Neuropsychiatry, Massachusetts General Hospital, USA.
Julie A ClancyDivision of Neuropsychiatry, Massachusetts General Hospital, USA.
Kayla M McEachernDivision of Neuropsychiatry, Massachusetts General Hospital, USA.
Tarek SobeihClinical Research Division, The Nathan Kline Institute for Psychiatric Research, USA.
Luis de TaboadaMonsabi, Inc, USA.
Thaddeus TarpeyDepartment of Population Health, New York University Grossman School of Medicine, USA.
Paolo CassanoDivision of Neuropsychiatry, Massachusetts General Hospital, USA; Department of Psychiatry, Harvard Medical School, USA.

Funding

Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)R01AG068248 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASSANO, PAOLO, IOSIFESCU, DAN VLAD · 2020 to 2024
$4.1M
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE)R33MH122647 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASSANO, PAOLO, IOSIFESCU, DAN VLAD · 2023 to 2025
$2.4M
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE)R61MH122647 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASSANO, PAOLO, IOSIFESCU, DAN VLAD · 2020 to 2021
$1.7M
NIA NIH HHS R01 AG068248NIMH NIH HHS R33 MH122647NIMH NIH HHS R61 MH122647
6 · The paper itself

Abstract

backgroundTranscranial photobiomodulation (t-PBM) with near-infrared light stimulates mitochondria and may have antidepressant effects. We evaluated dose-dependent effects of t-PBM on the hemodynamic blood-oxygenation-level-dependent (BOLD) power in major depressive disorder (MDD).

methods31 MDD subjects underwent randomly assigned t-PBM sessions, 1/week, in the MRI scanner, with 1) Sham; 2) High dose: pulse wave, irradiance ∼300 mW/cm

resultsWe found similar results in the MFG, the prefrontal cortex directly irradiated, and the entire brain cortex: medium dose t-PBM was associated with a statistically significant increase in BOLD power, whereas low dose t-PBM was associated with a significant decrease in BOLD. There were no significant changes in BOLD power with the high (pulsed) t-PBM dose or with sham. Single administrations of any t-PBM dose did not result in significant changes in depression severity (versus sham). All 3 t-PBM doses were well tolerated.

conclusionThe acute effect of t-PBM on the hemodynamic BOLD power is robust, dose-dependent, bidirectional, and extends beyond the areas directly illuminated. These findings may provide a reference for future dose selection and clinical efficacy studies.

Indexed as

BrainLow-Level Light TherapyMajor Depressive DisorderOxygenAdultDose-Response Relationship, RadiationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPrefrontal CortexYoung AdultOxygenBlood-oxygenation-level dependent (BOLD)Functional MRI (fMRI)Low level light therapyMajor depressive disorder (MDD)Near-infrared radiationTranscranial photobiomodulation

Identifiers

PMID42595101
PMCPMC13656166

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.