Evidence map›Paper›PMID 42594881›Full record

ArticleCell genomics2026

Single-cell transcriptomics provides insights into the stress-immune interplay and informs disease risk.

Sofia Benavides, Oksana Kosyk, Haiyang Wang, Alexander G Bastian, Christina Georgiou, Brian C Miller, Natalie Stanley, Anthony S Zannas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Stressed-out immune cells.Cell genomics · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sofia BenavidesDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA; UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Oksana KosykDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.
Haiyang WangLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alexander G BastianLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Christina GeorgiouDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.
Brian C MillerDepartment of Medicine, Division of Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Natalie StanleyDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Computer Science and Computational Medicine Program, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anthony S ZannasDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA; UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Carolina Stress Initiative, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA. Electronic address: anthony_zannas@med.unc.edu.

Funding

RESEARCH TRAINING IN THE NEUROSCIENCEST32NS007431 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Juan Song, Mark J. Zylka · 1997 to 2026
$10.0M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
Epigenetic mechanisms linking psychosocial stress with coronary heart diseaseR01HL163031 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Anthony S. Zannas · 2022 to 2026
$2.5M
Targeting Unique Myeloid Populations to Overcome Anti-PD-1 Resistance Conferred by Specific Cancer MutationsK08CA248960 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MILLER, BRIAN C · 2020 to 2024
$1.2M
Zeiss LSM 980 Confocal MicroscopeS10OD032388 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ITANO, MICHELLE S · 2022 to 2022
$597k
NCI NIH HHS K08 CA248960NHLBI NIH HHS R01 HL163031NICHD NIH HHS P50 HD103573NIH HHS S10 OD032388NINDS NIH HHS T32 NS007431
6 · The paper itself

Abstract

Environmental stress contributes to many diseases-including cardiovascular disease, mental illness, and autoimmune disorders-through immune dysregulation. Stress operates through the hypothalamic-pituitary-adrenal and sympathoadrenal axes, leading to peripheral secretion of cortisol and norepinephrine. While these stress hormones can profoundly influence immune function, their mechanistic effects at the cell-type level remain poorly understood. To address this knowledge gap, we employed an ex vivo model investigating the transcriptomic responses of primary peripheral blood mononuclear cells and neutrophils to physiological stress levels (i.e., levels reached during in vivo stress) of cortisol and norepinephrine at single-cell resolution. We identified novel stress-hormone-dependent and cell-type-specific transcriptomic changes, including uniquely regulated genes and inflammation-related signatures within distinct innate (e.g., CD163

Indexed as

Single-Cell AnalysisStress, PhysiologicalTranscriptomeGene Expression ProfilingHumansHydrocortisoneInflammationLeukocytes, MononuclearMonocytesNeutrophilsNorepinephrineSingle-Cell Gene Expression AnalysisHydrocortisoneNorepinephrinecatecholaminesCD163(+) monocytesglucocorticoidsimmune systemsingle-cell transcriptomicsstress

Identifiers

PMID42594881
PMCPMC13576718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.