Evidence map›Paper›PMID 42594877›Full record

ArticleCell reports. Medicine2026

Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans.

Luke Olsen, Javier Botella, Douglas Barrows, Ethan Romero, Kaitlyn Baird, Mutsumi Katayama, Ece Kilic, Christopher Peralta, Nadège Zanou, Henry Sanford and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Luke OlsenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA.
Javier BotellaInstitute for Health and Sport, Victoria University, Melbourne, VIC, Australia; Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Douglas BarrowsBioinformatics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Ethan RomeroWeill Cornell Medical College, New York, NY 10065, USA.
Kaitlyn BairdDepartment of Rehabilitation and Performance, Hospital for Special Surgery, New York, NY 10021, USA.
Mutsumi KatayamaDepartment of Physiology and Pharmacology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Ece KilicProteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Christopher PeraltaProteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Nadège ZanouInstitute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Henry SanfordLaboratory of Chemical Immunology and Proteomics, The Rockefeller University, New York, NY 10065, USA.
Laurie FarrellDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Christopher L AxelrodIntegrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Kaja PlucińskaLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA.
Jeanne WalkerThe Rockefeller University Hospital, New York, NY 10065, USA.
Lu YanDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Katie FredricksonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Olivier PourquieDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Jeremy M RobbinsDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Ekaterina V VinogradovaLaboratory of Chemical Immunology and Proteomics, The Rockefeller University, New York, NY 10065, USA.
Henrik MolinaProteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Nicolas PlaceInstitute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
John P KirwanIntegrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Juleen R ZierathDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.
Anna KrookDepartment of Physiology and Pharmacology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
David J BishopInstitute for Health and Sport, Victoria University, Melbourne, VIC, Australia.
Paul CohenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA. Electronic address: pcohen@rockefeller.edu.

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
An Encyclopedia of the Adipose Tissue Secretome to Identify Mediators of Health and DiseaseRC2DK129961 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T, COHEN, PAUL · 2021 to 2025
$9.2M
Proteomics of Cardiometabolic and Renal Traits in African AmericansR01HL133870 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROBERT E GERSZTEN · 2017 to 2026
$6.7M
Integrative analysis of genomics and proteomics to identify candidate molecular transducers of cardiorespiratory fitnessR03OD038387 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROBBINS, JEREMY · 2024 to 2024
$346k
NCATS NIH HHS UL1 TR001866NCATS NIH HHS UL1 TR004419NHLBI NIH HHS R01 HL133870NIDDK NIH HHS RC2 DK129961NIGMS NIH HHS U54 GM104940NIH HHS R03 OD038387
6 · The paper itself

Abstract

Exercise is an integral therapy for many cardiometabolic diseases, including obesity, type 2 diabetes, and hypertension. Despite its broad health benefits, the circulating factors that mediate exercise adaptations in humans remain incompletely defined, particularly across different exercise intensities. Here, we conducted a multi-cohort human exercise intervention incorporating sprint-interval exercise (SIE) and moderate-intensity exercise (MIE) to analyze intensity-dependent regulation of interorgan crosstalk. We found that exercise intensity distinctly influenced the plasma proteome and metabolome in untrained and trained participants. By integrating multi-organ gene and protein expression datasets with in vitro and in vivo tissue sampling, we mapped regulated proteins to their predicted tissues of origin and destination. Muscle fibers and adipocytes were particularly sensitive to exercise intensity and observed to undergo broad secretory and transcriptomic changes. Moreover, we leveraged a large-scale plasma-phenome database to identify intensity-dependent proteins associated with cardiometabolic health and disease, highlighting how exercise intensity differentially shapes interorgan communication and organismal health.

Indexed as

Cardiovascular DiseasesExerciseAdipocytesAdultFemaleHumansMaleMetabolomeProteomeTranscriptomeProteomeexerciseinterorgan crosstalkmetabolismmoderate-intensity exercisephysiologysprint-interval exercise

Identifiers

PMID42594877
PMCPMC13589506

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.