Evidence map›Paper›PMID 42594415›Full record

ReviewThe journal of prevention of Alzheimer's disease2026

Brain health strategies in middle-aged individuals with mild neurocognitive disorder: a scoping review.

Joshi Dookhy, Yvonne McCague, Jim Hickson, Diarmuid Stokes, Thilo Kroll, Kate Frazer

Abstract readReview
In one paragraph

Review in The journal of prevention of Alzheimer's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joshi DookhySchool of Nursing, Midwifery and Health Systems, University College Dublin, Dublin, Ireland; Neurology Department, University Hospital Galway, Galway, Ireland. Electronic address: joshi.dookhy@ucdconnect.ie.
Yvonne McCagueSchool of Nursing, Midwifery and Health Systems, University College Dublin, Dublin, Ireland; Regional Hospital Mullingar Co., Westmeath, Ireland. Electronic address: yvonne.mccague@ucdconnect.ie.
Jim HicksonSchool of Nursing, Midwifery and Health Systems, University College Dublin, Dublin, Ireland; Children's Health Ireland, Temple Street, Dublin, Ireland. Electronic address: jim.hickson1@ucdconnect.ie.
Diarmuid StokesJames Joyce Library, University College Dublin, Dublin, Ireland. Electronic address: diarmuid.stokes@ucd.ie.
Thilo KrollSchool of Nursing, Midwifery and Health Systems, University College Dublin, Dublin, Ireland. Electronic address: thilo.kroll@ucd.ie.
Kate FrazerSchool of Nursing, Midwifery and Health Systems, University College Dublin, Dublin, Ireland. Electronic address: kathleen.frazer@ucd.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain health refers to optimal brain functioning and integrity, shaped by complex cognitive, psychological, and social determinants. Individuals with mild neurocognitive disorder (mNCD) are at higher risk of developing dementia. Prioritising brain health is essential throughout the lifespan, particularly at midlife when health risks often emerge alongside heavy life responsibilities. International frameworks emphasise addressing modifiable risk factors across the lifespan to reduce dementia risk, yet little is known about the strategies middle-aged individuals with mNCD use to maintain brain health in everyday life. Understanding how people in midlife interpret and act on information about brain health is essential to align clinical care and prevention policies with lived experience. This scoping review followed the Joanna Briggs Institute methodology and mapped data published from August 2015 to 2025 using the 2024 Lancet Commission on dementia and the Cochrane PROGRESS-Plus equity framework. The primary aim of this review was to map the range and characteristics of non-pharmacological brain health strategies used by middle-aged individuals with mNCD to reduce the risks of developing dementia. After screening 6349 records, 17 articles were included. The results are presented in three groups: brain health strategies, facilitators and barriers across strategies, and the equity analysis. Strategies were classified as formalised interventions and self-directed practices. Facilitators and barriers varied according to population characteristics and the strategies used. Equity gaps included limited representation of study participants from rural and low-socioeconomic settings, reduced generalisability to male populations, and underrepresentation of minoritised ethnic groups. Clinicians, service planners, and policymakers should prioritise equity-oriented brain health strategies co-designed with middle-aged individuals. Equity and co-design should be explicitly integrated within global brain health policies and agendas.

Indexed as

Brain healthDementia risk reductionEquityMiddle-agedMild cognitive impairmentMild neurocognitive disorder

Identifiers

PMID42594415
PMCPMC13499126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.