ReviewAnnual review of genetics2026
Tuning Meiotic Checkpoints: Evolutionary Costs and Mechanistic Trade-Offs.
Review in Annual review of genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
Funding
Abstract
In this review, we discuss three meiotic checkpoints-the DNA damage response, the pachytene checkpoint, and the spindle checkpoint-and highlight their similarities and differences across diverse systems. Cell cycle checkpoints play a unique and important role during meiosis by enforcing dependencies within the complex choreography that governs chromosome behavior during meiotic prophase and chromosome segregation. However, meiotic checkpoints can exhibit dramatic variations in their stringency, especially when compared with mitotic checkpoints. This range in stringency likely reflects the mechanistic trade-offs associated with the unique goals of meiosis, as well as the evolutionary constraints and innovations inherent to the process.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.