ArticlePloS one2026
Prognostic value of the three-lineage cytopenia score in locally advanced nasopharyngeal carcinoma: A retrospective cohort study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Myelosuppression is common during chemoradiotherapy for nasopharyngeal carcinoma (NPC), but the prognostic impact of multilineage cytopenia remains unclear. This retrospective study evaluated a three-lineage cytopenia score in 576 patients with locally advanced NPC. The score (0-3) was defined as the number of lineages (leukocytes, hemoglobin, platelets) below normal limits. During a median follow-up of 74 months, higher cytopenia grades were significantly associated with worse overall survival, locoregional relapse-free survival, and distant metastasis-free survival (all P < 0.001). The score was an independent prognostic factor. Compared with score 0, score 3 was associated with a 7.55-fold increased risk of death (HR = 7.545, 95%CI: 3.158-18.028) and a 21.33-fold increased risk of distant metastasis (HR = 21.333, 95%CI: 5.076-89.655). The model incorporating the three-lineage cytopenia score yielded an area under the curve (AUC) of 0.593 (95% CI: 0.533-0.652, P = 0.001), indicating modest discriminatory ability. The three-lineage cytopenia score is a simple, independent prognostic indicator for locally advanced NPC with strong predictive value for distant metastasis. It may serve as a useful adjunct to traditional staging for risk stratification.
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