ArticleScience progress
Sex-specific associations of the CALLY index with mortality in hypertension: Stronger relative protection in males but greater absolute benefit in females-a retrospective cohort study.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveInflammation, immunity, and nutrition are established factors in hypertension, but the prognostic role of the C-reactive protein-albumin-lymphocyte (CALLY) index remains undefined. We aimed to clarify its impact on mortality.MethodsThis retrospective cohort study used data from the National Health and Nutrition Examination Survey (NHANES) 1999-2010.We identified 9,199 adults with hypertension and linked their records to the National Death Index to obtain mortality follow-up through December 31, 2019. The association between the CALLY index and both all-cause mortality (ACM) and cardiovascular mortality (CVM) was assessed using survey-weighted Cox proportional hazards models. To evaluate potential sex-specific differences, we performed sex-stratified subgroup analyses and quantified additive interactions via the relative excess risk due to interaction (RERI) and attributable proportion (AP).ResultsOver a median follow-up of 11.2 years, 3,259 ACM (35.4%) and 1,111 CVM (12.1%) occurred. Subgroup analyses showed numerically stronger inverse associations in males than females for both ACM (male: HR = 0.82; female: HR = 0.87) and CVM (male: HR = 0.79; female: HR = 0.90), although multiplicative interaction was not significant (ACM:
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.