Evidence map›Paper›PMID 42593962›Full record

ArticleSTAR protocols2026

Protocol for extrusion 3D bioprinting of human-scale cardiac patches using cardiac spheroid-laden bioinks.

Niina Matthews, Carmine Gentile

Abstract read
In one paragraph

Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Niina MatthewsUniversity of Technology Sydney, School of Electrical, Mechanical and Biomedical Engineering, Ultimo, NSW 2007, Australia. Electronic address: niina.matthews@student.uts.edu.au.
Carmine GentileUniversity of Technology Sydney, School of Electrical, Mechanical and Biomedical Engineering, Ultimo, NSW 2007, Australia; Heart Research Institute, Newtown, NSW 2042, Australia. Electronic address: carmine.gentile@uts.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extrusion-based bioprinting is a promising approach for developing novel clinical therapies for heart failure patients. Here, we present a protocol for bioprinting personalized human-scale cardiac patches incorporating human cardiac spheroids in a 1% silk fibroin/4% alginate/8% gelatin hydrogel. We describe steps for extrusion 3D bioprinting using a temperature-controlled hydrogel bioink. We also detail adjusting print parameters for optimal results. Although prepared for a specific experimental setup, the techniques described can be applied to other temperature-controlled biomaterials or extrusion 3D bioprinters. For complete details on the use and execution of this protocol, please refer to Roche et al.,

Indexed as

Cell cultureOrganoidsTissue Engineering

Identifiers

PMID42593962
PMCPMC13482210

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.