ArticleJournal of medicinal chemistry2026
Dissecting Structural and Functional Determinants of Microtubules Stabilization through Guided Chemical Modulation.
Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Illuminating microtubule functions with small molecules: past, present and future of fluorescent tubulin-binding probes.RSC chemical biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
Paclitaxel (PTX) is a widely used microtubule (MT) stabilizer whose clinical utility is limited by peripheral neuropathy, likely due to drug-induced structural perturbations of neuronal MTs. Here, we aimed to discern how taxane derivatives modify MT lattice architecture and how structural states regulate motor proteins and MAP dynamics. To decouple MT stabilization from adverse structural changes, we designed, synthesized, and characterized several PTX analogues. Our compound 1b retains PTX-like stabilizing activity in vitro and in cells while preserving a native-like MT lattice. This structural separation allowed direct interrogation of MT structure-function relationship in cells. PTX-induced lattice expansion disrupted dynein-mediated retrograde transport, altered kinesin-1 motility and suppressed dynamic Tau exchange. In contrast, 1b preserved more physiological Tau dynamics. These findings reveal that MT stabilization and lattice modulation are separable properties and establish drug-imposed MT states as regulators of intracellular transport and MAP behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.