ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2026
Extended Depth-of-Focus Intraocular Lens Based on Aberration-Neutral Technique.
Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purposeTo design an extended depth-of-focus (EDoF) intraocular lens (IOL) with a full-aperture aberration-neutral profile and to evaluate its optical stability under decentration and tilt using an anatomically accurate schematic eye model.
methodsIn this study, 'additional vision' refers to the functional intermediate/near vision range provided by the EDoF IOL beyond the distance focus. A new EDoF IOL based on the aberration-neutral technique was designed and optimised within the Navarro-Escudero model eye. Optical performance, including modulation transfer function through-object (MTF-TO), spot diagrams and ray tracing, was simulated under alignment, 0.5 mm decentration and 5° tilt using a numerical simulation method. Results were compared with a commercial monofocal IOL (IOL A) and two commercial EDoF IOLs (IOL B and IOL C) using the Liou-Brennan model eye.
resultsUnder perfect alignment, the new IOL achieved an MTF of 0.36 at 50 cycles/mm for distance and a continuous MTF-TO response from distance to near, confirming its EDoF functionality. Compared with IOL B and IOL C, the new design provided a wider depth of focus (1.2 D versus 1.1 D and 0.5 D) and a higher additional vision MTF (0.30 versus 0.19 and 0.27) under aligned conditions. Under 0.5 mm decentration, the distance MTF of the new IOL decreased by less than 3% (from 0.36 to 0.35), whereas IOL B and IOL C dropped to 0.09 and 0.23, respectively. Under 5° tilt, the additional vision MTF of the new IOL was 0.29, exceeding those of IOL B (0.20) and IOL C (0.19) by 45 and 53%, respectively. The MTF-TO curve showed no appreciable shift under tilt.
conclusionThe proposed full-aperture, system-level aberration-neutral EDoF IOL maintains stable optical quality and preserves both distance and additional vision under decentration and tilt. Its systematic evaluation using an anatomically accurate schematic eye model provides a robust theoretical basis for clinical application in eyes at risk of postoperative IOL misalignments.
Indexed as
Identifiers
42593656What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.