Evidence map›Paper›PMID 42593603›Full record

Trial reportJapanese journal of ophthalmology2026

Reduction in extraocular muscle and orbital fat volumes after teprotumumab treatment in Japanese patients with thyroid eye disease: an exploratory magnetic resonance imaging analysis from the OPTIC-J trial.

Ai Kozaki, Yasuhiro Takahashi, Yuji Tajiri, Zhenxun Wang, Tomoko Hayashida, Ada Kumar, Yuji Hiromatsu, Masashi Mimura

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ai KozakiOlympia Eye Hospital, 2-18-12 Jingumae, Shibuya-ku, Tokyo, 1500001, Japan. kouzaki@olympia.net.ORCID http://orcid.org/0000-0003-4643-320X
Yasuhiro TakahashiDepartment of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University Hospital, Nagakute, Aichi, Japan.
Yuji TajiriDivision of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Zhenxun WangAmgen Inc., Thousand Oaks, CA, USA.
Tomoko HayashidaAmgen Inc., Thousand Oaks, CA, USA.
Ada KumarAmgen Inc., Thousand Oaks, CA, USA.
Yuji HiromatsuDiabetes, Thyroid and Endocrine Center, Shin Koga Hospital, Kurume, Fukuoka, Japan.
Masashi MimuraOculoplastic Surgery Center, Department of Ophthalmology, Osaka Kaisei Hospital, Yodogawa-ku, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis substudy of the OPTIC-J trial analyzed magnetic resonance imaging (MRI) scans from a subset of Japanese patients to examine changes in orbital tissues after teprotumumab treatment vs placebo for active thyroid eye disease (TED). STUDY

designPost hoc exploratory.

methodsVolumes and inflammation/edema of extraocular muscles (EOMs) and orbital fat were measured before and after 24 weeks of teprotumumab treatment or placebo using MRI in patients enrolled at four of the 16 trial sites. Inflammation/edema in EOM and orbital fat were evaluated using the signal intensity ratio, based on T2 intensity in the cerebral white matter, and an ordinal grading scale (0-3), respectively. Key clinical outcomes included proptosis, diplopia, and clinical activity score (CAS).

resultsMean (%) changes in total EOM and orbital fat volumes in study eyes treated with teprotumumab (n = 6) and placebo (n = 8) were -1,022 mm

conclusionIn this OPTIC-J trial substudy, reductions in orbital soft tissue volumes and inflammation/edema were observed with MRI after teprotumumab treatment vs placebo; corresponding improvements in TED clinical outcomes were also observed.

Indexed as

Adipose TissueGraves OphthalmopathyMagnetic Resonance ImagingOculomotor MusclesOrbitAdultDouble-Blind MethodFemaleFollow-Up StudiesHumansJapanMaleMiddle AgedOrgan SizeTreatment OutcomeClinical trialGraves’ ophthalmopathyImagingInflammationMagnetic resonance imaging

Identifiers

PMID42593603
PMCPMC13615915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.