ArticleBreast cancer research and treatment2026
Fewer breast cancers during post-treatment surveillance among patients initially staged using contrast-based imaging.
Article in Breast cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe role of contrast-based imaging (CBI) at diagnosis in early breast cancer remains debated. More sensitive baseline staging may identify synchronous disease that would otherwise present as early ipsilateral or contralateral events. We examined whether CBI at diagnosis is associated with differences in early locoregional outcomes.
methodsA retrospective cohort study of women with early invasive breast cancer or ductal carcinoma in situ (DCIS). Patients were grouped according to whether they underwent CBI (CEM or MRI) at diagnosis. All underwent mammographic surveillance including contrast-enhanced mammography (CEM). Locoregional events from diagnosis to 30 June 2025 were identified and evaluated. Cox proportional hazards models to assess associations between CBI use and subsequent locoregional events were adjusted for age, calendar period, mammographic density (MD), and stage.
resultsAmong 1,106 women (594 CBI, 512 non-CBI) diagnosed between April 2015 and June 2022, there were 60 locoregional events (39 invasive, 21 DCIS). Patients who underwent CBI had fewer subsequent locoregional events. After adjustment, CBI use at diagnosis was associated with significantly lower 5-year event rates among women with invasive cancer (adjusted HR 0.50, 95% CI 0.26-0.98, p = 0.043), particularly those with Luminal A/B phenotypes, low MD, and with fewer contralateral events in invasive index cases (adjusted HR 0.19, 95% CI 0.05-0.71, p = 0.014). Features of subsequent events (including tumour grade, behaviour, and invasive size) were not found to differ between groups.
conclusionInclusion of CBI in local staging of early breast cancer was associated with lower rates of locoregional events over five years. These findings support broader consideration of CBI use for local staging at diagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.