ArticleDie Naturwissenschaften2026
Integrated network pharmacology, transcriptomics and proteomics unveils the mechanisms of Forsythiae Fructus against acute lung injury.
Article in Die Naturwissenschaften, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acute lung injury (ALI) is a life-threatening respiratory disorder with high mortality. Forsythiae Fructus (FF), a traditional Chinese medicine widely used for respiratory diseases, shows therapeutic potential against ALI, yet its underlying mechanisms remain poorly understood from a multi-omics perspective. This study integrated network pharmacology, transcriptomics, and proteomics to elucidate the protective mechanisms of FF against ALI. The chemical profile of FF was characterized by UPLC-Q-TOF-MS/MS, and an LPS-induced ALI rat model was established for pharmacodynamic evaluation. The optimal dose group was selected for multi-omics analysis. A total of 95 compounds were identified, and integrated analysis revealed that 11 core components mediated anti-ALI effects by modulating 347 targets across 25 signaling pathways. Molecular docking and Western blot validation demonstrated that these targets are primarily associated with the PI3K-Akt/mTOR, MAPK/ERK/p-38, JAK-STAT, and PPARγ signaling pathways. This study provides a comprehensive multi-omics framework for understanding the mechanisms of FF against ALI.
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