Evidence map›Paper›PMID 42593382›Full record

ArticleJACC. Case reports2026

Giant Left Atrial Appendage and Coronary Fistula With Microvascular Remodeling After Surgical Closure.

Yuki Ikeshita, Yojiro Machii, Hideaki Kanzaki, Atsushi Okada, Masashi Amano, Yoshihiko Ikeda, Tatsuya Nishii, Takeshi Kitai, Satsuki Fukushima, Chisato Izumi

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuki IkeshitaDepartment of Heart Failure and Transplantation, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan.
Yojiro MachiiDepartment of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan.
Hideaki KanzakiDepartment of Heart Failure and Transplantation, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan. Electronic address: kanzakih@ncvc.go.jp.
Atsushi OkadaDepartment of Heart Failure and Transplantation, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan.
Masashi AmanoDepartment of Heart Failure and Transplantation, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan.
Yoshihiko IkedaDepartment of Pathology, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan.
Tatsuya NishiiDepartment of Radiology, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan.
Takeshi KitaiDepartment of Heart Failure and Transplantation, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan.
Satsuki FukushimaDepartment of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan.
Chisato IzumiDepartment of Heart Failure and Transplantation, National Cerebral and Cardiovascular Center, Osaka, Suita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft atrial appendage (LAA) closure reduces stroke in patients with atrial fibrillation. CASE SUMMARY: A 63-year-old man with chronic atrial fibrillation had undergone mitral valve replacement and endocardial suture closure of the LAA 5 years before presentation. One year postoperatively, a giant LAA was noted, and coronary angiography revealed a newly developed coronary-LAA fistula. Progressive enlargement of the LAA was confirmed 5 years postoperatively, with expansion of the fistulous tract on coronary angiography, ultimately leading to surgical LAA resection. DISCUSSION: Incomplete suture closure might have caused microscopic residual flow and thrombus formation within the LAA despite anticoagulation. Additionally, we speculate that the fistula developed from postoperative microvascular remodeling, potentially serving as a pathway for blood flow into the LAA. LAA resection may represent a reasonable option in selected cases. TAKE-HOME MESSAGE: Postclosure LAA enlargement, though rare, warrants evaluation for coronary-LAA fistulae because reintervention may be required.

Indexed as

coronary fistulaLAA closureleft atrial appendagemicrovascular remodeling

Identifiers

PMID42593382
PMCPMC13669936

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.