Evidence map›Paper›PMID 42593124›Full record

ArticlemBio2026

Monoclonal antibodies target conserved S1

Jiaru Zhou, Ran Jing, Mengdi Zhang, Changcheng Liu, Yiming Li, Hongmei Zhu, Wenjuan Du, Anan Jongkaewwattana, Berend Jan Bosch, Guiqing Peng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiaru ZhouNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Ran JingNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Mengdi ZhangNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Changcheng LiuNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Yiming LiNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Hongmei ZhuNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Wenjuan DuCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
Anan JongkaewwattanaVirology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Klong Nueng, Thailand.
Berend Jan BoschVirology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.ORCID 0000-0002-3864-232X
Guiqing PengNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-8813-6663
Qigai HeNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-7005-7473
Mengjia ZhangNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0009-0008-5130-9549
Wentao LiNational Key Laboratory of Agricultural Microbiology, Hainan Research Institute, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0002-7114-762X

Funding

China Agricultural Research System of MOF and MARA CARS-35Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China JYB2025XDXM704Fundamental Research Funds for the Central Universities 2662026DKPY002, 2662026DKPY004, 2662023DKPY005Innovation Fund of International Joint Research Center of National Animal immunology 2025IJRCNAI09National Key Laboratory Foundation of Agricultural Microbiology AML2023A02National Natural Science Foundation of China 32272990, 32473007Self-designed research project for Hainan Institute of Huazhong Agricultural University 2025HZAUHNZS001Yingzi Tech & Huazhong Agricultural University Intelligent Research Institute of Food Health IRIFH202209
6 · The paper itself

Abstract

Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that causes severe diarrhea, vomiting, and dehydration in piglets, and a recent human infection report raises concerns about its zoonotic potential. The S1 subunit of the PDCoV-spike protein is the primary target of neutralizing antibodies and is critical for viral attachment and entry. In this study, we generated and characterized eight monoclonal antibodies (mAbs) against S1, two targeting the S1

Indexed as

Antibodies, MonoclonalAntibodies, ViralCoronavirus InfectionsDeltacoronavirusEpitopesSpike Glycoprotein, CoronavirusSwine DiseasesAnimalsAntibodies, NeutralizingChick EmbryoCross ReactionsHumansSwineAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopesSpike Glycoprotein, Coronaviruscross-reactivityembryonated chicken eggsfirefly luciferase reporter virusmonoclonal antibodiesporcine deltacoronavirus（PDCoV）virus neutralization

Identifiers

PMID42593124
PMCPMC13556247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.