SynthesisPsycho-oncology2026
Association Between Psychological Distress and Site-Specific Cancer Incidence: A Systematic Review and Meta-Analysis.
Synthesis in Psycho-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveDepression and anxiety are hypothesized to increase the risk for the development of chronic disease(s), including cancer. Several published observational studies and meta-analyses have investigated the link between depression and anxiety in cancer but have reported conflicting results. To clarify this relationship, a meta-analysis of observational studies reporting an association between depression, anxiety, and cancer incidence was performed.
methodsProspective and retrospective cohort studies investigating the relationship between depression, anxiety, and cancer incidence were included. A literature search of the PubMed was performed, with the final search conducted in March 2026. Egger's test and funnel plots were used to evaluate publication bias. Meta-analysis was performed using a random-effects model because high heterogeneity among the studies was expected.
resultsIn the analysis including both retrospective and prospective studies, patients with depression or anxiety exhibited an elevated risk for lung, hepatobiliary-pancreatic (HBP), hematological, and kidney, ureter, and bladder (KUB) cancers. In the analysis including only prospective studies, patients with depression or anxiety exhibited an elevated risk for female reproductive organ and lung cancer. Finally, in the analysis including only retrospective studies, patients with depression or anxiety exhibited an elevated risk for lung, HBP, hematological, KUB, and oral cancers, and a notably lower risk for female reproductive organ cancer.
conclusionsResults of this study revealed that depression and anxiety were associated with an elevated risk for specific cancers. A future meta-analysis including only prospective cohort studies with the same measures of depression or anxiety may further clarify this relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.