ArticleEncephalitis (Seoul, Korea)2026
Cuprizone-induced demyelination model mice exhibit antisocial maltreating behavior: an experimental animal study.
Article in Encephalitis (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Purpose: The structural integrity of white matter in the human brain, including myelination, is important not only for brain pathology but also for cognitive functions, including social behavior. Here, we investigated the relationship between myelination abnormalities and antisocial maltreating behavior in mice. Methods: The demyelination model was generated by feeding cuprizone to C57BL/6 mice. Luxol fast blue staining was performed to visualize myelin. The demyelination model was subjected to a maltreating behavioral task. Oxytocin (OXY), haloperidol (HAL), and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) were used. Results: The demyelination model mice showed a higher number of nose-pokes than the control. OXY or 8-OH-DPAT treatment reduced the high nose-poking number of the demyelination model mice. HAL did not largely affect the number of nose-pokes of the demyelination model mice. Conclusion: Demyelination appears to be closely related to antisocial maltreating behavior. Our maltreating-behavior assay system is a good animal system for investigating brain disorders involving antisocial or psychotic behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.