Evidence map›Paper›PMID 42592647›Full record

ArticleFEBS open bio2026

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U-87 MG cells.

Pragya Gupta, Sebastian Gb Furness, Tahereh Gharbi, Ric De Paoli-Iseppi, Shweta S Joshi, Michael Clark, David L Hare, Peter Wookey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pragya GuptaDepartment of Medicine (Austin Health, Heidelberg), University of Melbourne, Heidelberg, Australia.
Sebastian Gb FurnessSchool of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, Australia.
Tahereh GharbiDepartment of Medicine (Austin Health, Heidelberg), University of Melbourne, Heidelberg, Australia.
Ric De Paoli-IseppiDepartment of Anatomy and Physiology, University of Melbourne, Parkville, Australia.
Shweta S JoshiDepartment of Anatomy and Physiology, University of Melbourne, Parkville, Australia.
Michael ClarkDepartment of Anatomy and Physiology, University of Melbourne, Parkville, Australia.
David L HareDepartment of Medicine (Austin Health, Heidelberg), University of Melbourne, Heidelberg, Australia.
Peter WookeyDepartment of Medicine (Austin Health, Heidelberg), University of Melbourne, Heidelberg, Australia.ORCID https://orcid.org/0000-0002-3937-1621

Funding

Australian Research Council FT180100543University of Melbourne
6 · The paper itself

Abstract

Glioblastoma (GBM) is a highly lethal brain cancer in which the calcitonin receptor (CT Receptor), encoded by the CALCR gene, is expressed in 78-88% of patient biopsies. Here, we investigate whether the CT Receptor plays a role in cancer cell survival. In cancer cell lines, knockdown of CALCR disrupts the cell cycle and induces apoptosis, supporting an essential pro-survival role. The CALCR gene produces three main transcripts in humans, of which Transcript 1 encodes CALCR

Indexed as

alternative splicingapoptosisautophagycalcitonin receptorCTb Receptor isoformglioblastomananopore sequencing

Identifiers

PMID42592647
PMCPMC13470297

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.