Evidence map›Paper›PMID 42592588›Full record

ReviewCurrent therapeutic research, clinical and experimental2026

The effect of ascorbic acid supplementation on plasma leptin and adiponectin levels: Systematic review of

Mohammad Gholizadeh, Zahra Noushzadeh, Samira Movahed, Baharak Aghapour, Ahmadreza Kolahi, Parvin Mirmiran

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PubMed Full text at PMC Publisher
In one paragraph

Review in Current therapeutic research, clinical and experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad GholizadehDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra NoushzadehDepartment of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Samira MovahedDepartment of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Baharak AghapourDepartment of Health, Faculty of Medical Sciences, Sarab, Iran.
Ahmadreza KolahiDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Parvin MirmiranDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Leptin plays a key role in regulating energy balance and lipid reserves. Leptin has a broad spectrum of regulatory actions. Adiponectin, an adipokine released by adipocytes, is recognized as an important factor in maintaining balance of blood glucose levels, lipid metabolism and insulin sensitivity. Recent studies have investigated the role of Ascorbic acid (AA) in the management of metabolic syndrome or the effect of high dose AA supplementation on serum AA, leptin and cortisol parameters. Purpose: The purpose of the current systematic review was to identify associations between AA supplementation and plasma leptin and adiponectin level Methods: Comprehensive systematic search was performed in the PubMed/Medline, SCOPUS, and Web of Science databases up to 14 May 2026. A total of 948 studies were initially searched, 187 from PubMed, 204 from the Web of Science, and 557 from Scopus databases. After excluding the duplicates, the remaining 435 articles were screened by reviewing the title and abstract, and 411 unrelated articles were excluded. Of the remaining 24 articles, 9 articles met our inclusion/exclusion. Results: The results obtained from the Conclusion: This systematic review demonstrates a positive relationship between AA and adiponectin and inverse relationship with leptin.

Indexed as

AdiponectinAscorbic acidIn vitroIn vivoLeptinReviewVitamin C

Identifiers

PMID42592588
PMCPMC13464371

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.