Evidence map›Paper›PMID 42592511›Full record

ArticleRegenerative biomaterials2026

A gradient core-shell microsphere to enable effective embolization of liver cancer via interventional therapy.

Hongtao Sun, Lijuan Yao, Xin Wang, Hao Xu, Chaozhou Li, Xin Li, Lin Yu, Haibo Che, Peng Sun, Yinghua Zou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongtao SunState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.
Lijuan YaoCardiolink Science (Shenzhen) Medical Technology Development Co., Ltd, Shenzhen 518122, China.
Xin WangState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.
Hao XuInterventional Radiology Department, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, China.
Chaozhou LiCardiolink Science (Shenzhen) Medical Technology Development Co., Ltd, Shenzhen 518122, China.
Xin LiCardiolink Science (Shenzhen) Medical Technology Development Co., Ltd, Shenzhen 518122, China.
Lin YuState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.
Haibo CheCardiolink Science (Shenzhen) Medical Technology Development Co., Ltd, Shenzhen 518122, China.
Peng SunCardiolink Science (Shenzhen) Medical Technology Development Co., Ltd, Shenzhen 518122, China.
Yinghua ZouDepartment of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing 100034, China.
Jiandong DingState Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embolic microspheres are important for the interventional treatment of solid tumors, but it is a dilemma for microspheres to keep sufficient strength and resilience. Herein, we propose a strategy to fabricate core-shell poly(vinyl alcohol) microspheres with gradient crosslinking (GCL) on an industrial scale to solve the dilemma. The synthesized GCL microspheres exhibit superior mechanical characteristics in comparison to the homogeneous microspheres and the conventional core-shell microspheres produced by standard one-step and two-step methods, respectively. An

Indexed as

embolizationinterventional treatmentliver cancermicrospherepolymerpoly(vinyl alcohol)

Identifiers

PMID42592511
PMCPMC13466941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.