Evidence map›Paper›PMID 42592454›Full record

ArticleActa pharmaceutica Sinica. B2026

Neutralizing dentin sialophosphoprotein facilitates tumor vascular normalization in colorectal cancer by blocking the crosstalk between tumor cells and endothelial cells.

Chaoqun Liu, Rui Zhou, Weiwei Liu, Rui Li, Jun Xiao, Jianghua Wu, Ziyan Ning, Zilin Chen, Cheng Qian, Yujie Zhang and 2 more

Abstract read
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In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chaoqun LiuDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Rui ZhouDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Weiwei LiuDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Rui LiDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Jun XiaoDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Jianghua WuDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Ziyan NingDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Zilin ChenDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Cheng QianDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Yujie ZhangDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Wandie LinDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Liang ZhaoDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irregular, curved, and uneven shapes of tumor vessels contribute to a malignant microenvironment, promoting metastasis. In this study, using patient-derived xenograft models, we observed that tumors derived from metastatic colorectal cancer (CRC) tissues exhibited increased vascular density, hypoxia, and permeability, but reduced perfusion and pericyte coverage, compared with tumors derived from non-metastatic CRC tissues. We conducted a high-throughput microarray analysis to determine the molecular mechanisms underlying compromised vessel structures. Dentin sialophosphoprotein (

Indexed as

Colorectal cancerDSPPIntegrin αvβ3Interleukin-17 FMAPK pathwayMetastasisMicroenvironmentTumor vessel normalization

Identifiers

PMID42592454
PMCPMC13464568

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.