Evidence map›Paper›PMID 42592443›Full record

ArticleJournal of cytology

The International System for Reporting Serous Fluid Cytopathology: The Need for Version 2.0.

Padmini C Vijayasarathy, Shanmugapriya Shankar, Anil K Sirasagi, Chinmayi Saravanane

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Article in Journal of cytology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Padmini C VijayasarathyDepartment of Pathology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
Shanmugapriya ShankarDepartment of Pathology, ESIC Medical College and PGIMSR, Bengaluru, Karnataka, India.
Anil K SirasagiDepartment of Pathology, ESIC Medical College and PGIMSR, Bengaluru, Karnataka, India.
Chinmayi SaravananeDepartment of Pathology, ESIC Medical College and PGIMSR, Bengaluru, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Serous effusion cytopathology, of neoplastic and non-neoplastic origin, when feasible, should be coupled with ancillary procedures for the detection of malignancies. "The International System for Reporting Serous Fluid Cytopathology" (TIS) categorizes into nondiagnostic (ND), negative for malignancy (NFM), atypical cells of undetermined significance (AUS), suspicious for malignancy (SFM), and malignant (MAL) categories to establish better communication between pathologists and clinicians. Aims: This study aimed to reclassify the serous body fluids according to TIS and assess their risk of malignancy (ROM). Materials and Methods: A retrospective cross-sectional study was conducted in the Department of Pathology for a period of 4.5 years after obtaining clearance from the Institutional Ethics Committee. Serous effusions, having corresponding cell block or tissue biopsy, were recategorized as per the TIS, and ROM was calculated for all categories. Continuous variables were represented as ranges, medians, and means. Results: This study included 370 fluids. The majority (224 samples, 60.5%) comprised ascitic fluid, followed by 136 pleural fluids (36.7%). ND, NFM, AUS, SFM, and MAL categories had 7 (1.89%) cases, 285 (77%) cases, 6 (1.62%) cases, 15 (4.05%) cases, and 57 (15.4%) cases with ROM of 14.28%, 10.82%, 83.33%, 86.66%, and 100.00%, respectively. ANOVA and chi-square tests showed a Conclusions: TIS is a standardized and efficient approach in categorizing serous body fluids. Due to the close ROM observed in the AUS and SFM categories, there lies a scope for finer refinement of the criteria for the AUS category.

Indexed as

1. The International System for Reporting Serous Fluid Cytopathology is a system that has introduced discipline in reporting body fluid cytopathology by using categories like nondiagnostic, negative for malignancy, atypical cells of undetermined significance (AUS), suspicious for malignancy (SFM), and malignant.2. The category AUS has not been frequently used in routine reporting in the past, and this study showed the AUS category to have a very close risk of malignancy to the SFM category.3. There is a requirement for finer refinement of the cytopathological criteria for classifying the cases under the AUS category.Cytologyeffusionsserous fluidsstandardizationthe international system

Identifiers

PMID42592443
PMCPMC13466618

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