Evidence map›Paper›PMID 42592428›Full record

ArticleActa pharmaceutica Sinica. B2026

Cytoplasmic relocation of nuclear Ku70 by Bruceine A augments cGAS-STING pathway-mediated anti-tumor immunity.

Kai Huang, Zhaohui Tang, Qin Gong, Jianing Peng, Yicheng Rong, Tiancong Wu, Weichen Song, Siyu Mao, Yugui Xia, Wenjie Guo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kai HuangState Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Nanjing Drum Tower Hospital, School of Life Science, Nanjing University, Nanjing 210093, China.
Zhaohui TangState Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Nanjing Drum Tower Hospital, School of Life Science, Nanjing University, Nanjing 210093, China.
Qin GongState Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Nanjing Drum Tower Hospital, School of Life Science, Nanjing University, Nanjing 210093, China.
Jianing PengFaculty of Life Sciences, University College London, Gower Street, London WC1E6BT, UK.
Yicheng RongState Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Nanjing Drum Tower Hospital, School of Life Science, Nanjing University, Nanjing 210093, China.
Tiancong WuDepartment of Radiation Oncology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China.
Weichen SongState Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Nanjing Drum Tower Hospital, School of Life Science, Nanjing University, Nanjing 210093, China.
Siyu MaoState Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Nanjing Drum Tower Hospital, School of Life Science, Nanjing University, Nanjing 210093, China.
Yugui XiaInstitute of Artificial Intelligence Biomedicine, Nanjing University, Nanjing 210093, China.
Wenjie GuoState Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Nanjing Drum Tower Hospital, School of Life Science, Nanjing University, Nanjing 210093, China.
Wen LiuState Key Laboratory of Pharmaceutical Biotechnology, Department of Gastroenterology, Nanjing Drum Tower Hospital, School of Life Science, Nanjing University, Nanjing 210093, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA-damaging agents combined with agonists of the cGAS-STING pathway can effectively suppress colorectal cancer (CRC) by inducing cancer cell death and eliciting an antitumor immune response. In this study, we demonstrate that the natural compound Bruceine A (BA) inhibits CRC progression through a dual mechanism involving nuclear-to-cytoplasmic translocation of Ku70. Cytoplasmic Ku70 loses its canonical DNA repair function while simultaneously enhancing its interaction with cGAS, leading to increased cGAS oligomerization and elevated levels of double-stranded DNA (dsDNA), both of which amplify cGAS-STING signaling. Furthermore, Bruceine A-mediated Ku70 translocation exacerbates DNA damage accumulation, further enhancing tumor immunogenicity. In the murine CRC model, Bruceine A significantly inhibited tumor growth and enhanced tumor sensitivity to chemotherapy, radiotherapy, and anti-PD-1 treatment. Notably, genetic ablation of STING and CD8

Indexed as

Anti-tumor immunityBruceine AcGAS–STING signalChemotherapyColorectal cancerDNA damage repairKu70Radiotherapy

Identifiers

PMID42592428
PMCPMC13464071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.